DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, CS | - |
dc.contributor.author | Shemorry, A | - |
dc.contributor.author | Varshavsky, A | - |
dc.date.accessioned | 2016-04-01T02:22:07Z | - |
dc.date.available | 2016-04-01T02:22:07Z | - |
dc.date.created | 2011-03-22 | - |
dc.date.issued | 2010-02-19 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.other | 2010-OAK-0000022970 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/25000 | - |
dc.description.abstract | The retained N-terminal methionine (Met) residue of a nascent protein is often N-terminally acetylated (Nt-acetylated). Removal of N-terminal Met by Met-aminopeptidases frequently leads to Nt-acetylation of the resulting N-terminal alanine (Ala), valine (Val), serine (Ser), threonine (Thr), and cysteine (Cys) residues. Although a majority of eukaryotic proteins (for example, more than 80% of human proteins) are cotranslationally Nt-acetylated, the function of this extensively studied modification is largely unknown. Using the yeast Saccharomyces cerevisiae, we found that the Nt-acetylated Met residue could act as a degradation signal (degron), targeted by the Doa10 ubiquitin ligase. Moreover, Doa10 also recognized the Nt-acetylated Ala, Val, Ser, Thr, and Cys residues. Several examined proteins of diverse functions contained these N-terminal degrons, termed N-Ac-degrons, which are a prevalent class of degradation signals in cellular proteins. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.relation.isPartOf | SCIENCE | - |
dc.subject | END RULE PATHWAY | - |
dc.subject | UBIQUITIN LIGASE | - |
dc.subject | MAT-ALPHA-2 REPRESSOR | - |
dc.subject | YEAST | - |
dc.subject | ACETYLTRANSFERASE | - |
dc.subject | PROTEOMICS | - |
dc.subject | RETICULUM | - |
dc.subject | MEMBRANE | - |
dc.subject | SENSOR | - |
dc.subject | GENES | - |
dc.title | N-terminal acetylation of cellular proteins creates specific degradation signals | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1126/SCIENCE.1183147 | - |
dc.author.google | Hwang, CS | - |
dc.author.google | Shemorry, A | - |
dc.author.google | Varshavsky, A | - |
dc.relation.volume | 327 | - |
dc.relation.issue | 5968 | - |
dc.relation.startpage | 973 | - |
dc.relation.lastpage | 977 | - |
dc.contributor.id | 10966770 | - |
dc.relation.journal | SCIENCE | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | SCIENCE, v.327, no.5968, pp.973 - 977 | - |
dc.identifier.wosid | 000274625800033 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 977 | - |
dc.citation.number | 5968 | - |
dc.citation.startPage | 973 | - |
dc.citation.title | SCIENCE | - |
dc.citation.volume | 327 | - |
dc.contributor.affiliatedAuthor | Hwang, CS | - |
dc.identifier.scopusid | 2-s2.0-77149120798 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 308 | - |
dc.description.scptc | 291 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | END RULE PATHWAY | - |
dc.subject.keywordPlus | UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | MAT-ALPHA-2 REPRESSOR | - |
dc.subject.keywordPlus | YEAST | - |
dc.subject.keywordPlus | ACETYLTRANSFERASE | - |
dc.subject.keywordPlus | PROTEOMICS | - |
dc.subject.keywordPlus | RETICULUM | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | SENSOR | - |
dc.subject.keywordPlus | GENES | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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