Focal transient ischemia increases APP-BP1 expression in neural progenitor cells
SCIE
SCOPUS
- Title
- Focal transient ischemia increases APP-BP1 expression in neural progenitor cells
- Authors
- Joo, Y; Lee, SH; Ha, S; Hong, BH; Kim, JH; Suh, YH; Kim, HS
- Date Issued
- 2011-03-30
- Publisher
- Lippincott
- Abstract
- Amyloid precursor protein binding protein-1 (APP-BP1) binds to the carboxyl terminus of APP. In this study, we explored whether APP-BP1 expression is affected by focal transient cerebral ischemia induced by middle cerebral artery occlusion in Wistar rats. APP-BP1 expression was increased in the dentate gyrus of the hippocampus and in the subventricular zone of rats exposed to focal transient cerebral ischemia. In addition, APP-BP1 immunoreactivity overlapped with antidoublecortin and anti-5-bromo-2deoxyuridine labeling. Focal transient cerebral ischemia has been reported earlier to induce neurogenesis in adult brains. The upregulation of APP-BP1 expression in neural progenitor cells after focal transient ischemia suggests that this protein contributes to the neurogenesis induced by transient ischemia and reperfusion. NeuroReport 22:200-205 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
- Keywords
- Alzheimer' s disease; amyloid precursor protein binding protein-1; focal cerebral ischemia; middle cerebral artery occlusion; neurogenesis; AMYLOID PRECURSOR PROTEIN; CENTRAL-NERVOUS-SYSTEM; ALZHEIMERS-DISEASE; TERMINAL REGION; ADULT BRAIN; NEUROGENESIS; STROKE; NEDD8; FE65; APP
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/25003
- DOI
- 10.1097/WNR.0B013E32834449CF
- ISSN
- 0959-4965
- Article Type
- Article
- Citation
- NEUROREPORT, vol. 22, no. 5, page. 200 - 205, 2011-03-30
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