Replication Quality of Flow-through Microfilters in Microfluidic Lab-on-a-Chip for Blood Typing by Microinjection Molding
SCIE
SCOPUS
- Title
- Replication Quality of Flow-through Microfilters in Microfluidic Lab-on-a-Chip for Blood Typing by Microinjection Molding
- Authors
- Lee, BK; Chul Jin Hwang; Kim, DS; Tai Hun Kwon
- Date Issued
- 2008-04
- Publisher
- ASME-AMER SOC MECHANICAL ENG
- Abstract
- In the present study, replication of flow-through microfilters in the newly developed microfluidic lab-on-a-chip for blood typing by microinjection molding process was experimentally investigated. As a precise replication of the microfilters was required in order to effectively filter out agglutinated red blood cells, the effects of important processing conditions on the replication of the flow-through microfilters were investigated. By using a mold insert fabricated by a nickel electroplating process and a newly designed mold base, microinjection molding experiments were carried out. A three-dimensional solid model reconstruction method was proposed with the help of specific features characterizing the geometry of microfilters, and accordingly, the feature values of the replicated microfilters were measured by a noncontact optical measurement system. So reconstructed solid modeling result was then used to investigate the effects of various processing conditions, such as a flow rate, a mold temperature, and a packing pressure. Amongst the processing conditions investigated in the present study, the flow rate was found to be the most important one.
- Keywords
- microinjection molding; lab-on-a-chip; microfluidic system; microfilter; replication quality; SIMULATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/25019
- DOI
- 10.1115/1.2896142
- ISSN
- 1087-1357
- Article Type
- Article
- Citation
- JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME, vol. 130, no. 2, page. 21010, 2008-04
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