DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, J | - |
dc.contributor.author | Kim, ES | - |
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Park, CW | - |
dc.contributor.author | Cha, HJ | - |
dc.contributor.author | Hong, BH | - |
dc.contributor.author | Choi, KY | - |
dc.date.accessioned | 2016-04-01T02:26:05Z | - |
dc.date.available | 2016-04-01T02:26:05Z | - |
dc.date.created | 2011-02-10 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 2005-0380 | - |
dc.identifier.other | 2011-OAK-0000022731 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/25123 | - |
dc.description.abstract | Objective: The aim of this study was to identify apoptosis-related genes of ovarian cancer cell lines following cisplatin treatment. Methods: We used IC(50) values and fluorescence-activated cell sorting analysis to compare cell death in 2 ovarian cancer cell lines, namely, SKOV-3 and OVCAR-3, upon treatment with cisplatin. Moreover, the change in transcriptional levels of apoptosis-associated genes was measured with a dendron-modified DNA microarray. Results: The protein levels for the up-regulated genes in each cell line were validated to identify the molecules that may determine the cellular behavior of cisplatin resistance. Eight genes were over-expressed in the 2 cell lines. The cisplatin-induced up-regulation of DAD1 in transcriptional and protein levels contributed to the cisplatin resistance of OVCAR-3, and the up-regulation of FASTK and TNFRSF11A in SKOV-3 resulted in its higher sensitivity to cisplatin than that of OVCAR-3. Conclusion: In the present study, we have identified a set of genes responsible for apoptosis following cisplatin treatment in ovarian cancer cell lines. These genes may give information about the understanding of cisplatin-induced apoptosis in ovarian cancer. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | KOREAN SOC GYNECOLOGY ONCOLOGY & COLPOSCOPY | - |
dc.relation.isPartOf | JOURNAL OF GYNECOLOGIC ONCOLOGY | - |
dc.subject | Ovarian cancer cell lines | - |
dc.subject | Cisplatin | - |
dc.subject | Apoptosis | - |
dc.subject | Dendron-modified DNA microarray | - |
dc.subject | CDNA MICROARRAY | - |
dc.subject | TUMOR-CELLS | - |
dc.subject | DNA-REPAIR | - |
dc.subject | RESISTANCE | - |
dc.subject | IDENTIFICATION | - |
dc.subject | ACCUMULATION | - |
dc.subject | CARCINOMA | - |
dc.subject | RESPONSES | - |
dc.subject | PROTEINS | - |
dc.subject | DEATH | - |
dc.title | Apoptosis-related mRNA expression profiles of ovarian cancer cell lines following cisplatin treatment | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.3802/JGO.2010.21.4.255 | - |
dc.author.google | Yoon, J | - |
dc.author.google | Kim, ES | - |
dc.author.google | Lee, SJ | - |
dc.author.google | Park, CW | - |
dc.author.google | Cha, HJ | - |
dc.author.google | Hong, BH | - |
dc.author.google | Choi, KY | - |
dc.relation.volume | 21 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 255 | - |
dc.relation.lastpage | 261 | - |
dc.contributor.id | 10052985 | - |
dc.relation.journal | JOURNAL OF GYNECOLOGIC ONCOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF GYNECOLOGIC ONCOLOGY, v.21, no.4, pp.255 - 261 | - |
dc.identifier.wosid | 000285808900009 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 261 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 255 | - |
dc.citation.title | JOURNAL OF GYNECOLOGIC ONCOLOGY | - |
dc.citation.volume | 21 | - |
dc.contributor.affiliatedAuthor | Choi, KY | - |
dc.identifier.scopusid | 2-s2.0-79952409033 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 4 | - |
dc.description.scptc | 4 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CDNA MICROARRAY | - |
dc.subject.keywordPlus | TUMOR-CELLS | - |
dc.subject.keywordPlus | DNA-REPAIR | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordAuthor | Ovarian cancer cell lines | - |
dc.subject.keywordAuthor | Cisplatin | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Dendron-modified DNA microarray | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
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