The Topographic Effect of Zinc Oxide Nanoflowers on Osteoblast Growth and Osseointegration

Abstract

ZnO nanoflowers prepared by a solution-based hydrothermal growth method result in effective osteoblast growth with higher DNA content, ALP activity, and adhesion strength than those on ZnO film. Furthermore, ZnO nanoflowers are tightly osseointegrated into the regenerated bones. The approach for fabricating nanoflower structures on biomaterial surfaces can be successfully exploited for various bone tissue engineering applications.