DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, DY | - |
dc.contributor.author | Woo Kyung Chul | - |
dc.contributor.author | Lee Kyung Ha | - |
dc.contributor.author | Kim Tae Don | - |
dc.contributor.author | KIM, KYONG TAI | - |
dc.date.accessioned | 2016-04-01T02:31:22Z | - |
dc.date.available | 2016-04-01T02:31:22Z | - |
dc.date.created | 2010-12-17 | - |
dc.date.issued | 2010-11 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.other | 2010-OAK-0000022428 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/25289 | - |
dc.description.abstract | The physiological and behavioral circadian rhythms of most creatures are controlled by a harmony of functional relationships between clock genes. In mammals, several core clock genes show rhythmic profiles of their mRNA and protein expression. Among them, Rev-erb alpha functions as a transcriptional repressor, affecting expression patterns of other clock genes. For the continuous and robust oscillation of the molecular clock system, the levels of Rev-erb alpha protein are expected to be tightly regulated with the correct timing. Here, we demonstrate that Rev-erb alpha has an internal ribosomal entry site (IRES) in its 5' untranslated region. Furthermore, we demonstrate that heterogeneous nuclear ribonucleoprotein Q and polypyrimidine tract-binding protein (PTB) modulate the IRES-mediated translation of Rev-erb alpha. We suggest that the rhythmic binding affinity of hnRNP Q to the Rev-erb alpha IRES and the change in PTB cytosolic levels lead to maintenance of the oscillation profile of the Rev-erb alpha protein. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.relation.isPartOf | NUCLEIC ACIDS RESEARCH | - |
dc.title | hnRNP Q and PTB modulate the circadian oscillation of mouse Rev-erb alpha via IRES-mediated translation | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1093/NAR/GKQ569 | - |
dc.author.google | Kim, DY | - |
dc.author.google | Woo, KC | - |
dc.author.google | Lee, KH | - |
dc.author.google | Kim, TD | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 38 | - |
dc.relation.issue | 20 | - |
dc.relation.startpage | 7068 | - |
dc.relation.lastpage | 7078 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | NUCLEIC ACIDS RESEARCH | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NUCLEIC ACIDS RESEARCH, v.38, no.20, pp.7068 - 7078 | - |
dc.identifier.wosid | 000284165100028 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 7078 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 7068 | - |
dc.citation.title | NUCLEIC ACIDS RESEARCH | - |
dc.citation.volume | 38 | - |
dc.contributor.affiliatedAuthor | Kim, DY | - |
dc.contributor.affiliatedAuthor | KIM, KYONG TAI | - |
dc.identifier.scopusid | 2-s2.0-78651324818 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 31 | - |
dc.description.scptc | 31 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | INTERNAL INITIATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | MAMMALIAN CLOCK | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | RHYTHMS | - |
dc.subject.keywordPlus | EVENTS | - |
dc.subject.keywordPlus | LOOPS | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.