DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, JH | - |
dc.contributor.author | Choi, HJ | - |
dc.contributor.author | Maeng, YS | - |
dc.contributor.author | Choi, JY | - |
dc.contributor.author | Kim, M | - |
dc.contributor.author | Kwon, JY | - |
dc.contributor.author | Park, YW | - |
dc.contributor.author | Kim, YM | - |
dc.contributor.author | Hwang, D | - |
dc.contributor.author | Kwon, YG | - |
dc.date.accessioned | 2016-04-01T02:32:31Z | - |
dc.date.available | 2016-04-01T02:32:31Z | - |
dc.date.created | 2010-12-07 | - |
dc.date.issued | 2010-10-01 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 2010-OAK-0000022376 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/25322 | - |
dc.description.abstract | Mel-18 is a mammalian homolog of Polycomb group (PcG) genes. Microarray analysis revealed that Mel-18 expression was induced during endothelial progenitor cell (EPC) differentiation and correlates with the expression of EC-specific protein markers. Overexpression of Mel-18 promoted EPC differentiation and angiogenic activity of ECs. Accordingly, silencing Mel-18 inhibited EC migration and tube formation in vitro. Gene expression profiling showed that Mel-18 regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2. Our findings demonstrate, for the first time, that Mel-18 plays a significant role in the angiogenic function of ECs by regulating endothelial gene expression. (C) 2010 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | Mel-18 | - |
dc.subject | Polycomb group gene | - |
dc.subject | Endothelial cells | - |
dc.subject | Differentiation | - |
dc.subject | Angiogenesis | - |
dc.subject | PROGENITOR CELLS | - |
dc.subject | MICE | - |
dc.title | Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1016/J.BBRC.2010.08.086 | - |
dc.author.google | Jung, JH | - |
dc.author.google | Choi, HJ | - |
dc.author.google | Maeng, YS | - |
dc.author.google | Choi, JY | - |
dc.author.google | Kim, M | - |
dc.author.google | Kwon, JY | - |
dc.author.google | Park, YW | - |
dc.author.google | Kim, YM | - |
dc.author.google | Hwang, D | - |
dc.author.google | Kwon, YG | - |
dc.relation.volume | 400 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 523 | - |
dc.relation.lastpage | 530 | - |
dc.contributor.id | 10180943 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.400, no.4, pp.523 - 530 | - |
dc.identifier.wosid | 000282850500013 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 530 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 523 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 400 | - |
dc.contributor.affiliatedAuthor | Hwang, D | - |
dc.identifier.scopusid | 2-s2.0-77957277896 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 6 | - |
dc.description.scptc | 5 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Mel-18 | - |
dc.subject.keywordAuthor | Polycomb group gene | - |
dc.subject.keywordAuthor | Endothelial cells | - |
dc.subject.keywordAuthor | Differentiation | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.