DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, HM | - |
dc.contributor.author | Choi, EJ | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Kim, TD | - |
dc.contributor.author | Kim, YK | - |
dc.contributor.author | Kang, C | - |
dc.contributor.author | Gho, YS | - |
dc.date.accessioned | 2016-04-01T02:41:27Z | - |
dc.date.available | 2016-04-01T02:41:27Z | - |
dc.date.created | 2010-11-24 | - |
dc.date.issued | 2010-06-25 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 2010-OAK-0000021975 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/25593 | - |
dc.description.abstract | While intercellular adhesion molecule-1 (ICAM-1) is a transmembrane protein, two types of extracellular ICAM-1 have been detected in cell culture supernatants as well as in the serum: a soluble form of ICAM-1 (sICAM-1) and a membranous form of ICAM-1 (mICAM-1) associated with exosomes. Previous observations have demonstrated that sICAM-1 cannot exert potent immune modulatory activity due to its low affinity for leukocyte function-associated antigen-1 (LFA-1) or membrane attack complex-1. In this report, we initially observed that human cancer cells shed mICAM-1(+)-exosomes but were devoid of vascular cell adhesion molecule-1 and E-selectin. We demonstrate that mICAM-1 on exosomes retained its topology similar to that of cell surface ICAM-1, and could bind to leukocytes. In addition, we show that exosomal mICAM-1 exhibits potent anti-leukocyte adhesion activity to tumor necrosis factor-a-activated endothelial cells compared to that of sICAM-1. Taken together with previous findings, our results indicate that mICAM-1 on exosomes exhibits potent immune modulatory activity. (C) 2010 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | ICAM-1 | - |
dc.subject | Exosomes | - |
dc.subject | Microparticles | - |
dc.subject | Communicasome | - |
dc.subject | Inflammation | - |
dc.subject | Endothelial cell | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | CANCER CELLS | - |
dc.subject | MOLECULE-1 | - |
dc.subject | MICROVESICLES | - |
dc.subject | VESICLES | - |
dc.subject | MICROPARTICLES | - |
dc.subject | DIMERIZATION | - |
dc.subject | DISTINCT | - |
dc.subject | SICAM-1 | - |
dc.title | A membranous form of ICAM-1 on exosomes efficiently blocks leukocyte adhesion to activated endothelial cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.BBRC.2010.05.094 | - |
dc.author.google | Lee, HM | - |
dc.author.google | Choi, EJ | - |
dc.author.google | Kim, JH | - |
dc.author.google | Kim, TD | - |
dc.author.google | Kim, YK | - |
dc.author.google | Kang, C | - |
dc.author.google | Gho, YS | - |
dc.relation.volume | 397 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 251 | - |
dc.relation.lastpage | 256 | - |
dc.contributor.id | 10103891 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.397, no.2, pp.251 - 256 | - |
dc.identifier.wosid | 000279718900023 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 256 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 251 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 397 | - |
dc.contributor.affiliatedAuthor | Gho, YS | - |
dc.identifier.scopusid | 2-s2.0-77955496871 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 33 | - |
dc.description.scptc | 29 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | MOLECULE-1 | - |
dc.subject.keywordPlus | MICROVESICLES | - |
dc.subject.keywordPlus | VESICLES | - |
dc.subject.keywordPlus | MICROPARTICLES | - |
dc.subject.keywordPlus | DIMERIZATION | - |
dc.subject.keywordPlus | DISTINCT | - |
dc.subject.keywordPlus | SICAM-1 | - |
dc.subject.keywordAuthor | ICAM-1 | - |
dc.subject.keywordAuthor | Exosomes | - |
dc.subject.keywordAuthor | Microparticles | - |
dc.subject.keywordAuthor | Communicasome | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Endothelial cell | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
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