DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, KS | - |
dc.contributor.author | Choi, KH | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Hong, BS | - |
dc.contributor.author | Kim, OY | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Yoon, CM | - |
dc.contributor.author | Koh, GY | - |
dc.contributor.author | Kim, YK | - |
dc.contributor.author | Gho, YS | - |
dc.date.accessioned | 2016-04-01T02:44:02Z | - |
dc.date.available | 2016-04-01T02:44:02Z | - |
dc.date.created | 2010-11-24 | - |
dc.date.issued | 2010-06-28 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.other | 2010-OAK-0000021843 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/25671 | - |
dc.description.abstract | Sepsis, characterized by a systemic inflammatory state that is usually related to Gram-negative bacterial infection, is a leading cause of death worldwide. Although the annual incidence of sepsis is still rising, the exact cause of Gram-negative bacteria-associated sepsis is not clear. Outer membrane vesicles (OMVs), constitutively secreted from Gram-negative bacteria, are nano-sized spherical bilayered proteolipids. Using a mouse model, we showed that intraperitoneal injection of OMVs derived from intestinal Escherichia coli induced lethality. Furthermore, OMVs induced host responses which resemble a clinically relevant condition like sepsis that was characterized by piloerection, eye exudates, hypothermia, tachypnea, leukopenia, disseminated intravascular coagulation, dysfunction of the lungs, hypotension, and systemic induction of tumor necrosis factor-alpha and interleukin-6. Our study revealed a previously unidentified causative microbial signal in the pathogenesis of sepsis, suggesting OMVs as a new therapeutic target to prevent and/or treat severe sepsis caused by Gram-negative bacterial infection. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.title | Outer Membrane Vesicles Derived from Escherichia coli Induce Systemic Inflammatory Response Syndrome | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1371/JOURNAL.PONE.0011334 | - |
dc.author.google | Park, KS | - |
dc.author.google | Choi, KH | - |
dc.author.google | Kim, YS | - |
dc.author.google | Hong, BS | - |
dc.author.google | Kim, OY | - |
dc.author.google | Kim, JH | - |
dc.author.google | Yoon, CM | - |
dc.author.google | Koh, GY | - |
dc.author.google | Kim, YK | - |
dc.author.google | Gho, YS | - |
dc.relation.volume | 5 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | E11334 | - |
dc.contributor.id | 10138843 | - |
dc.relation.journal | PLOS ONE | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.5, no.6, pp.E11334 | - |
dc.identifier.wosid | 000279259900007 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | E11334 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | Gho, YS | - |
dc.identifier.scopusid | 2-s2.0-77955321899 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 58 | - |
dc.description.scptc | 52 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ZEA-MAYS L | - |
dc.subject.keywordPlus | NEISSERIA-MENINGITIDIS | - |
dc.subject.keywordPlus | PERIPLASMIC PROTEINS | - |
dc.subject.keywordPlus | CYTOKINE PRODUCTION | - |
dc.subject.keywordPlus | SEVERE SEPSIS | - |
dc.subject.keywordPlus | SEPTIC SHOCK | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | ORGAN | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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