DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, HW | - |
dc.contributor.author | Ha, SH | - |
dc.contributor.author | Lee, MN | - |
dc.contributor.author | Huston, E | - |
dc.contributor.author | Kim, DH | - |
dc.contributor.author | JANG, SUNG KEY | - |
dc.contributor.author | Suh, PG | - |
dc.contributor.author | Houslay, MD | - |
dc.contributor.author | Ryu, SH | - |
dc.date.accessioned | 2016-04-01T02:44:42Z | - |
dc.date.available | 2016-04-01T02:44:42Z | - |
dc.date.created | 2010-12-16 | - |
dc.date.issued | 2010-11 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.other | 2010-OAK-0000021812 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/25689 | - |
dc.description.abstract | The mammalian target of rapamycin complex 1 (mTORC1) is a molecular hub that regulates protein synthesis in response to a number of extracellular stimuli. Cyclic AMP (cAMP) is considered to be an important second messenger that controls mTOR; however, the signaling components of this pathway have not yet been elucidated. Here, we identify cAMP phosphodiesterase 4D (PDE4D) as a binding partner of Rheb that acts as a cAMP-specific negative regulator of mTORC1. Under basal conditions, PDE4D binds Rheb in a noncatalytic manner that does not require its cAMP-hydrolyzing activity and thereby inhibits the ability of Rheb to activate mTORC1. However, elevated cAMP levels disrupt the interaction of PDE4D with Rheb and increase the interaction between Rheb and mTOR. This enhanced Rheb-mTOR interaction induces the activation of mTORC1 and cap-dependent translation, a cellular function of mTORC1. Taken together, our results suggest a novel regulatory mechanism for mTORC1 in which the cAMP-determined dynamic interaction between Rheb and PDE4D provides a key, unique regulatory event. We also propose a new role for PDE4 as a molecular transducer for cAMP signaling. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.title | Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1128/MCB.00217-10 | - |
dc.author.google | Kim, HW | - |
dc.author.google | Ha, SH | - |
dc.author.google | Lee, MN | - |
dc.author.google | Huston, E | - |
dc.author.google | Kim, DH | - |
dc.author.google | Jang, SK | - |
dc.author.google | Suh, PG | - |
dc.author.google | Houslay, MD | - |
dc.author.google | Ryu, SH | - |
dc.relation.volume | 30 | - |
dc.relation.issue | 22 | - |
dc.relation.startpage | 5406 | - |
dc.relation.lastpage | 5420 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR BIOLOGY, v.30, no.22, pp.5406 - 5420 | - |
dc.identifier.wosid | 000283656700013 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 5420 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 5406 | - |
dc.citation.title | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.citation.volume | 30 | - |
dc.contributor.affiliatedAuthor | JANG, SUNG KEY | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-78649567118 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 30 | - |
dc.description.scptc | 33 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CAMP-SPECIFIC PHOSPHODIESTERASE | - |
dc.subject.keywordPlus | DEPENDENT PROTEIN-KINASE | - |
dc.subject.keywordPlus | THYROID-STIMULATING HORMONE | - |
dc.subject.keywordPlus | CELL-GROWTH | - |
dc.subject.keywordPlus | TUBEROUS SCLEROSIS | - |
dc.subject.keywordPlus | MAMMALIAN TARGET | - |
dc.subject.keywordPlus | BETA-ARRESTIN | - |
dc.subject.keywordPlus | ADENINE RIBONUCLEOTIDE | - |
dc.subject.keywordPlus | CARDIAC MYOCYTES | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.