DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, HJ | - |
dc.contributor.author | Song, MY | - |
dc.contributor.author | Choi, DH | - |
dc.contributor.author | Yang, SH | - |
dc.contributor.author | Jin, HT | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2016-04-01T02:46:24Z | - |
dc.date.available | 2016-04-01T02:46:24Z | - |
dc.date.created | 2010-09-27 | - |
dc.date.issued | 2010-02 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.other | 2010-OAK-0000021683 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/25738 | - |
dc.description.abstract | IL-7 plays a crucial role in the homeostatic proliferation, differentiation and survival of T cells, as well as in the survival and proliferation of precursor B cells. Here, we demonstrated that utilizing nonlytic Fc-fused IL-7 (IL-7-Fc(m)) as a genetic adjuvant significantly enhanced not only CD4(+) but also CD8(+) T-cell responses by E7 DNA immunization, in addition to improving protection against TC-1-induced tumors in comparison to IL-7 alone. Similar results were obtained in OT-1 adoptive transfer experiments with OVA DNA injection, suggesting independence from antigenic nature and experimental conditions. In particular, the increased frequency of CD8(+) T cells was mainly due to enhanced T-cell proliferation in T-cell priming, and not to decreased cellular apoptosis. Interestingly, the enhanced adjuvant effect was not seen in the co-delivery of lytic Fc-fused IL-7 (IL-7-Fc) which increases T-cell apoptosis as well as T-cell proliferation, suggesting that the T-cell proliferative effect may be neutralized by T-cell apoptosis. Thus, our findings suggest that nonlytic Fc, in contrast to lytic Fc, fusion to cytokines may provide an insight in designing a potent genetic adjuvant for inducing CD4(+) and CD8(+) T-cell responses. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | WILEY-VCH | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.subject | IL-7 | - |
dc.subject | Lytic and nonlytic Fc fusion | - |
dc.subject | T-cell responses | - |
dc.subject | Vaccination | - |
dc.subject | IN-VIVO | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | IL-15 | - |
dc.subject | INTERLEUKIN-7 | - |
dc.subject | HOMEOSTASIS | - |
dc.subject | ANTIBODIES | - |
dc.subject | RECEPTORS | - |
dc.subject | MICE | - |
dc.subject | IMMUNOTHERAPY | - |
dc.subject | COMPLEXES | - |
dc.title | Marked enhancement of antigen-specific T cell responses by IL-7-fused nonlytic, but not lytic, Fc as a genetic adjuvant. | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1002/EJI.200939271 | - |
dc.author.google | Nam, HJ | - |
dc.author.google | Song, MY | - |
dc.author.google | Choi, DH | - |
dc.author.google | Yang, SH | - |
dc.author.google | Jin, HT | - |
dc.author.google | Sung, YC | - |
dc.relation.volume | 40 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 351 | - |
dc.relation.lastpage | 358 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF IMMUNOLOGY, v.40, no.2, pp.351 - 358 | - |
dc.identifier.wosid | 000274670300009 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 358 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 351 | - |
dc.citation.title | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 40 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-75149194434 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 14 | - |
dc.description.scptc | 15 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | IL-15 | - |
dc.subject.keywordPlus | INTERLEUKIN-7 | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordAuthor | IL-7 | - |
dc.subject.keywordAuthor | Lytic and nonlytic Fc fusion | - |
dc.subject.keywordAuthor | T-cell responses | - |
dc.subject.keywordAuthor | Vaccination | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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