DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ochieng, W | - |
dc.contributor.author | Sauermann, U | - |
dc.contributor.author | Schulte, R | - |
dc.contributor.author | Suh, YS | - |
dc.contributor.author | Kim, KS | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Hunsmann, G | - |
dc.contributor.author | Stahl-Hennig, C | - |
dc.contributor.author | Sopper, S | - |
dc.date.accessioned | 2016-04-01T02:59:07Z | - |
dc.date.available | 2016-04-01T02:59:07Z | - |
dc.date.created | 2010-04-28 | - |
dc.date.issued | 2009-10-01 | - |
dc.identifier.issn | 1525-4135 | - |
dc.identifier.other | 2009-OAK-0000020969 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/26089 | - |
dc.description.abstract | Background: Efficacy assessment of AIDS vaccines relies both on preclinically challenging immunized monkeys with simian immunodeficiency virus (SIV) or monitoring infection rates in large human trials. Although conventional parameters of vaccine-induced immune responses do not completely predict outcome, existing methods for testing cellular immunity are sophisticated and difficult to establish in resource-limited settings. Methods: We have used virus replication kinetics (VVR) on ConA-stimulated peripheral blood mononuclear cells from rhesus monkeys immunized with DNA replication-defective adenovirus vector expressing various SIV genes, as an ex vivo model, to mimic the effects of different immune effector functions on viral infection. Results: VVR was attenuated by the immunization and correlated 2 weeks after first boost, with the number of interferon gamma-secreting cells and T-cell noncytotoxic antiviral responses. Importantly, VVR on the day of challenge but not interferon gamma responses correlated with viremia and with memory CD4+ T-cell measurements after SIVmac239 challenge. Similarly, T-cell noncytotoxic antiviral responses on the day of challenge correlated directly with memory CD4(+) T cell and inversely with plasma viremia after challenge. Conclusions: VVR thus served as a better predictor of protective capacity of the vaccine regimen in these monkeys. We suggest that VVR be considered in the evaluation of candidate AIDS vaccines in humans. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.isPartOf | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | - |
dc.subject | correlate of protection | - |
dc.subject | HIV | - |
dc.subject | in vitro replication | - |
dc.subject | immune response | - |
dc.subject | immunization | - |
dc.subject | ANTI-HIV RESPONSE | - |
dc.subject | T-CELL RESPONSES | - |
dc.subject | RHESUS MACAQUES | - |
dc.subject | IN-VITRO | - |
dc.subject | DISEASE PROGRESSION | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | REPLICATION | - |
dc.subject | INFECTION | - |
dc.subject | DNA | - |
dc.subject | MONKEYS | - |
dc.title | Susceptibility to Simian Immunodeficiency Virus Ex Vivo Predicts Outcome of a Prime-Boost Vaccine After SIVmac239 Challenge | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1097/QAI.0b013e3181b22f4a | - |
dc.author.google | Ochieng, W | - |
dc.author.google | Sauermann, U | - |
dc.author.google | Schulte, R | - |
dc.author.google | Suh, YS | - |
dc.author.google | Kim, KS | - |
dc.author.google | Sung, YC | - |
dc.author.google | Hunsmann, G | - |
dc.author.google | Stahl-Hennig, C | - |
dc.author.google | Sopper, S | - |
dc.relation.volume | 52 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 162 | - |
dc.relation.lastpage | 169 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v.52, no.2, pp.162 - 169 | - |
dc.identifier.wosid | 000270206500003 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 169 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 162 | - |
dc.citation.title | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | - |
dc.citation.volume | 52 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-70349676021 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 3 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ANTI-HIV RESPONSE | - |
dc.subject.keywordPlus | MEMORY T-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | RHESUS MACAQUES | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | IMMUNOGENICITY | - |
dc.subject.keywordPlus | AIDS | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordAuthor | correlate of protection | - |
dc.subject.keywordAuthor | HIV | - |
dc.subject.keywordAuthor | in vitro replication | - |
dc.subject.keywordAuthor | immune response | - |
dc.subject.keywordAuthor | immunization | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
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