DC Field | Value | Language |
---|---|---|
dc.contributor.author | Schulte, R | - |
dc.contributor.author | Suh, YS | - |
dc.contributor.author | Sauermann, U | - |
dc.contributor.author | Ochieng, W | - |
dc.contributor.author | Sopper, S | - |
dc.contributor.author | Kim, KS | - |
dc.contributor.author | Ahn, SS | - |
dc.contributor.author | Park, KS | - |
dc.contributor.author | Stolte-Leeb, N | - |
dc.contributor.author | Hunsmann, G | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Stahl-Hennig, C | - |
dc.date.accessioned | 2016-04-01T03:02:12Z | - |
dc.date.available | 2016-04-01T03:02:12Z | - |
dc.date.created | 2010-04-28 | - |
dc.date.issued | 2009-01-20 | - |
dc.identifier.issn | 0042-6822 | - |
dc.identifier.other | 2009-OAK-0000020857 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/26166 | - |
dc.description.abstract | We investigated the immunogenicity and efficacy of a bimodal prime/boost vaccine regimen given by various routes in the Simian immunodeficiency virus (SIV) rhesus monkey model for AIDS. Twelve animals were immunized with SIV DNA-vectors followed by the application of a recombinant adenovirus (rAd5) expressing the same genes either intramuscularly (i.m.) or by oropharyngeal spray. The second rAd5-application was given i.m. All vaccinees plus six controls were challenged orally with SIVmac239 12 weeks post-final immunization. Both immunization strategies induced strong SIV Gag-specific IFN-gamma and T-cell proliferation responses and mediated a conservation of CD4(+) memory T-cells and a reduction of viral load during peak viremia following infection. Interestingly, the mucosal group was superior to the systemic group regarding breadth and strength of SIV-specific T-cell responses and exhibited lower vector specific immune responses. Therefore, our data warrant the inclusion of mucosal vector application in a vaccination regimen which makes it less invasive and easier to apply. (c) 2008 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | VIROLOGY | - |
dc.subject | SIV | - |
dc.subject | Mucosal immunization | - |
dc.subject | Adenovirus | - |
dc.subject | Vaccine | - |
dc.subject | Macaque | - |
dc.subject | SIMIAN-IMMUNODEFICIENCY-VIRUS | - |
dc.subject | T-CELL RESPONSES | - |
dc.subject | REPLICATION-DEFECTIVE ADENOVIRUS | - |
dc.subject | RHESUS MACAQUES | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | NEUTRALIZING ANTIBODIES | - |
dc.subject | CYNOMOLGUS MONKEYS | - |
dc.subject | TIANTAN VACCINIA | - |
dc.subject | VECTOR VACCINE | - |
dc.subject | INFECTION | - |
dc.title | Mucosal prior to systemic application of recombinant adenovirus boosting is more immunogenic than systemic application twice but confers similar protection against SIV-challenge in DNA vaccine-primed | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1016/J.VIROL.2008.10.012 | - |
dc.author.google | Schulte, R | - |
dc.author.google | Suh, YS | - |
dc.author.google | Sauermann, U | - |
dc.author.google | Ochieng, W | - |
dc.author.google | Sopper, S | - |
dc.author.google | Kim, KS | - |
dc.author.google | Ahn, SS | - |
dc.author.google | Park, KS | - |
dc.author.google | Stolte-Leeb, N | - |
dc.author.google | Hunsmann, G | - |
dc.author.google | Sung, YC | - |
dc.author.google | Stahl-Hennig, C | - |
dc.relation.volume | 383 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 300 | - |
dc.relation.lastpage | 309 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | VIROLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | VIROLOGY, v.383, no.2, pp.300 - 309 | - |
dc.identifier.wosid | 000262605700015 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 309 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 300 | - |
dc.citation.title | VIROLOGY | - |
dc.citation.volume | 383 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-58149105397 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 14 | - |
dc.description.scptc | 14 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | REPLICATION-DEFECTIVE ADENOVIRUS | - |
dc.subject.keywordPlus | MEMORY T-CELLS | - |
dc.subject.keywordPlus | RHESUS MACAQUES | - |
dc.subject.keywordPlus | NEUTRALIZING ANTIBODIES | - |
dc.subject.keywordPlus | CYNOMOLGUS MONKEYS | - |
dc.subject.keywordPlus | CELLULAR-IMMUNITY | - |
dc.subject.keywordPlus | TIANTAN VACCINIA | - |
dc.subject.keywordPlus | VECTOR VACCINE | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordAuthor | SIV | - |
dc.subject.keywordAuthor | Mucosal immunization | - |
dc.subject.keywordAuthor | Adenovirus | - |
dc.subject.keywordAuthor | Vaccine | - |
dc.subject.keywordAuthor | Macaque | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
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