DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Bahn, JW | - |
dc.contributor.author | Kim, YK | - |
dc.contributor.author | Chang, YS | - |
dc.contributor.author | Shin, ES | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Park, JS | - |
dc.contributor.author | Kim, BH | - |
dc.contributor.author | Jang, IJ | - |
dc.contributor.author | Song, J | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Park, HS | - |
dc.contributor.author | Min, KU | - |
dc.contributor.author | Jee, YK | - |
dc.date.accessioned | 2016-04-01T03:03:30Z | - |
dc.date.available | 2016-04-01T03:03:30Z | - |
dc.date.created | 2010-04-28 | - |
dc.date.issued | 2009-11 | - |
dc.identifier.issn | 1462-2416 | - |
dc.identifier.other | 2009-OAK-0000020823 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/26196 | - |
dc.description.abstract | Aims: Although some genetic risk factors have been reported for the development of hepatitis due to anti-TB drugs, an extensive candidate gene approach evaluating drug-metabolizing enzymes has not been attempted. This study aimed to investigate the association of genetic polymorphisms in drug-metabolizing enzymes with anti-TB drug-induced hepatitis. Materials & methods: We compared genotype distributions of tagging SNPs in promoter, exons and haplotypes in seven drug-metabolizing enzyme genes (CYP2C9, CYP2C19, CYP2D6, CYP2E1, NAT2, UGT1A1 and UGT1A3) between 67 cases and 159 controls. Results: Among four tagging SNPs of N-acetyltransferase 2 (NAT2), -9796T>A in promoter and R197Q were significantly associated (p = 0.0016 and p = 0.0007, respectively). NAT2 haplotype 2 [A-A-A-G] carrying A allele of -9796T>A and A allele of R197Q showed significant association (p = 0.0004). However, there was no significant association between genotypes of other enzyme-metabolizing genes and anti-TB drug-induced hepatitis. The constructs containing -9796A of NAT2 showed significantly lower luciferase activity (p < 0.01), suggesting decreased expression of NAT2. The variant alleles and haplotype 2 showed significantly higher peak serum levels of isoniazid, lower acetyl isoniazid:isoniazid ratio and lower isoniazid clearance compared with wild-types. Conclusion: These findings suggest that genetic variants in the promoter and exons of NAT2 increase the risk of anti-TB drug-induced hepatitis by modifying acetylation phenotypes and/or gene expression of NAT2, and there is no essential role for genetic mutation of the other metabolizing enzymes in the development of this adverse reaction. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | FUTURE MEDICINE LTD | - |
dc.relation.isPartOf | PHARMACOGENOMICS | - |
dc.subject | anti-TB drug | - |
dc.subject | drug-metabolizing enzyme | - |
dc.subject | hepatitis | - |
dc.subject | N-acetyltransferase 2 | - |
dc.subject | polymorphism | - |
dc.subject | ISONIAZID-INDUCED HEPATOTOXICITY | - |
dc.subject | 1ST-LINE ANTITUBERCULOSIS DRUGS | - |
dc.subject | S-TRANSFERASE M1 | - |
dc.subject | RISK-FACTORS | - |
dc.subject | N-ACETYLTRANSFERASE-2 GENE | - |
dc.subject | HAPLOTYPE ANALYSIS | - |
dc.subject | TUBERCULOSIS | - |
dc.subject | ASSOCIATION | - |
dc.subject | POPULATION | - |
dc.subject | GENOTYPE | - |
dc.title | Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.2217/PGS.09.100 | - |
dc.author.google | Kim, SH | - |
dc.author.google | Bahn, JW | - |
dc.author.google | Kim, YK | - |
dc.author.google | Chang, YS | - |
dc.author.google | Shin, ES | - |
dc.author.google | Kim, YS | - |
dc.author.google | Park, JS | - |
dc.author.google | Kim, BH | - |
dc.author.google | Jang, IJ | - |
dc.author.google | Song, J | - |
dc.author.google | Park, HS | - |
dc.author.google | Min, KU | - |
dc.author.google | Jee, YK | - |
dc.relation.volume | 10 | - |
dc.relation.issue | 11 | - |
dc.relation.startpage | 1767 | - |
dc.relation.lastpage | 1779 | - |
dc.contributor.id | 10103891 | - |
dc.relation.journal | PHARMACOGENOMICS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PHARMACOGENOMICS, v.10, no.11, pp.1767 - 1779 | - |
dc.identifier.wosid | 000272024300012 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1779 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1767 | - |
dc.citation.title | PHARMACOGENOMICS | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Kim, YK | - |
dc.identifier.scopusid | 2-s2.0-70649093029 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 48 | - |
dc.description.scptc | 49 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ISONIAZID-INDUCED HEPATOTOXICITY | - |
dc.subject.keywordPlus | 1ST-LINE ANTITUBERCULOSIS DRUGS | - |
dc.subject.keywordPlus | S-TRANSFERASE M1 | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | N-ACETYLTRANSFERASE-2 GENE | - |
dc.subject.keywordPlus | HAPLOTYPE ANALYSIS | - |
dc.subject.keywordPlus | GENOTYPE | - |
dc.subject.keywordPlus | NAT2 | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordAuthor | anti-TB drug | - |
dc.subject.keywordAuthor | drug-metabolizing enzyme | - |
dc.subject.keywordAuthor | hepatitis | - |
dc.subject.keywordAuthor | N-acetyltransferase 2 | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.