DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yea, K | - |
dc.contributor.author | Kim, J | - |
dc.contributor.author | Yoon, JH | - |
dc.contributor.author | Kwon, T | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Lee, BD | - |
dc.contributor.author | Lee, HJ | - |
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Kim, JI | - |
dc.contributor.author | Lee, TG | - |
dc.contributor.author | Baek, MC | - |
dc.contributor.author | Park, HS | - |
dc.contributor.author | Park, KS | - |
dc.contributor.author | Ohba, M | - |
dc.contributor.author | Suh, PG | - |
dc.contributor.author | Ryu, SH | - |
dc.date.accessioned | 2016-04-01T03:07:15Z | - |
dc.date.available | 2016-04-01T03:07:15Z | - |
dc.date.created | 2010-03-31 | - |
dc.date.issued | 2009-12-04 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.other | 2009-OAK-0000020695 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/26279 | - |
dc.description.abstract | Glucose homeostasis is maintained by the orchestration of peripheral glucose utilization and hepatic glucose production, mainly by insulin. In this study, we found by utilizing a combined parallel chromatography mass profiling approach that lysophosphatidylcholine (LPC) regulates glucose levels. LPC was found to stimulate glucose uptake in 3T3-L1 adipocytes dose- and time-dependently, and this activity was found to be sensitive to variations in acyl chain lengths and to polar head group types in LPC. Treatment with LPC resulted in a significant increase in the level of GLUT4 at the plasma membranes of 3T3-L1 adipocytes. Moreover, LPC did not affect IRS-1 and AKT2 phosphorylations, and LPC-induced glucose uptake was not influenced by pretreatment with the PI 3-kinase inhibitor LY294002. However, glucose uptake stimulation by LPC was abrogated both by rottlerin (a protein kinase C delta inhibitor) and by the adenoviral expression of dominant negative protein kinase C delta. In line with its determined cellular functions, LPC was found to lower blood glucose levels in normal mice. Furthermore, LPC improved blood glucose levels in mouse models of type 1 and 2 diabetes. These results suggest that an understanding of the mode of action of LPC may provide a new perspective of glucose homeostasis. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.subject | GLUT4 TRANSLOCATION | - |
dc.subject | COUPLED RECEPTOR | - |
dc.subject | 3T3-L1 ADIPOCYTES | - |
dc.subject | INSULIN | - |
dc.subject | ACID | - |
dc.subject | TRANSPORT | - |
dc.subject | CELLS | - |
dc.subject | EXERCISE | - |
dc.title | Lysophosphatidylcholine Activates Adipocyte Glucose Uptake and Lowers Blood Glucose Levels in Murine Models of Diabetes | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1074/JBC.M109.024869 | - |
dc.author.google | Yea, K | - |
dc.author.google | Kim, J | - |
dc.author.google | Yoon, JH | - |
dc.author.google | Kwon, T | - |
dc.author.google | Kim, JH | - |
dc.author.google | Lee, BD | - |
dc.author.google | Lee, HJ | - |
dc.author.google | Lee, SJ | - |
dc.author.google | Kim, JI | - |
dc.author.google | Lee, TG | - |
dc.author.google | Baek, MC | - |
dc.author.google | Park, HS | - |
dc.author.google | Park, KS | - |
dc.author.google | Ohba, M | - |
dc.author.google | Suh, PG | - |
dc.author.google | Ryu, SH | - |
dc.relation.volume | 284 | - |
dc.relation.issue | 49 | - |
dc.relation.startpage | 33833 | - |
dc.relation.lastpage | 33840 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.284, no.49, pp.33833 - 33840 | - |
dc.identifier.wosid | 000272165200015 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 33840 | - |
dc.citation.number | 49 | - |
dc.citation.startPage | 33833 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 284 | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-71749095787 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 55 | - |
dc.description.scptc | 47 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTOR | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | GLUT4 TRANSLOCATION | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | EXERCISE | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | KERATINOCYTES | - |
dc.subject.keywordPlus | INCREASES | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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