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Short-term plasticity of small synaptic vesicle (SSV) and large dense-core vesicle (LDCV) exocytosis SCIE SCOPUS

Title
Short-term plasticity of small synaptic vesicle (SSV) and large dense-core vesicle (LDCV) exocytosis
Authors
Park, YKim, KT
Date Issued
2009-10
Publisher
ELSEVIER SCIENCE INC
Abstract
Synaptic plasticity results from changes in the strength of synaptic transmission upon repetitive stimulation. The amount of neurotransmitter released from presynaptic terminals can regulate short-term plasticity that lasts for a few minutes. This review focuses on short-term plasticity of small synaptic vesicle (SSV) and large dense-core vesicle (LDCV) exocytosis. Whereas SSVs contain classical neurotransmitters and activate ion channels, LDCVs contain neuropeptides and hormones which primarily activate G protein-coupled receptors (GPCRs). Thus, LDCV exocytosis is mainly associated with modulation of synaptic activity and cannot induce synaptic activity by itself. As in SSV exocytosis, repetitive stimulation leads to short-term enhancement of LDCV exocytosis: i.e., activity-dependent potentiation (ADP) which represents potentiation of neurotransmitter release. Short-term plasticity of SSV exocytosis results from Ca2+ accumulation, but ADP of LDCV exocytosis does not. Here, we review the signaling mechanisms and differences of short-term plasticity in exocytotic processes of SSV and LDCV. (C) 2009 Elsevier Inc. All rights reserved.
Keywords
Exocytosis; Potentiation; Short-term plasticity; Large dense-core vesicle; Small synaptic vesicle; PROTEIN-KINASE-C; ADRENAL CHROMAFFIN CELLS; KISS-AND-RUN; ACTIVITY-DEPENDENT POTENTIATION; FROG NEUROMUSCULAR-JUNCTION; TRANSMITTER RELEASE; NEUROTRANSMITTER RELEASE; POSTTETANIC POTENTIATION; CALCIUM-CHANNEL; PRESYNAPTIC PLASTICITY
URI
https://oasis.postech.ac.kr/handle/2014.oak/26468
DOI
10.1016/J.CELLSIG.2009.02.015
ISSN
0898-6568
Article Type
Article
Citation
CELLULAR SIGNALLING, vol. 21, no. 10, page. 1465 - 1470, 2009-10
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김경태KIM, KYONG TAI
Dept of Life Sciences
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