In-vitro study on haemodiluted blood flow in a sinusoidal microstenosis
SCIE
SCOPUS
- Title
- In-vitro study on haemodiluted blood flow in a sinusoidal microstenosis
- Authors
- Kang, MJ; Ji, HS; Lee, SJ
- Date Issued
- 2010-01
- Publisher
- PROFESSIONAL ENGINEERING PUBLISHING LTD
- Abstract
- In-vitro experiments were carried out to investigate the haemodynamic and haemorheological behaviours of haemodiluted blood flow through a microstenosis using a micro-particle image velocimetry (PM technique. The micro-PIV system employed in this study consisted of a two-head neodymium:yttrium-aluminium-garnet (Nd:YAG) laser, a cooled charge-coupled device camera, and a delay generator. To simulate blood flow in a stenosed vascular vessel, a polydimethylsiloxane (PDMS) microchannel with a sinusoidal throat of 80 per cent severity was employed. The width and depth of the microchannel were 100 mu m and 50 mu m, respectively. To compare the flow characteristics in the microstenosis, the same experiments were repeated in a straight microchannel under the same flow conditions. Using a syringe pump, human blood with 5 per cent haematocrit was supplied into the microstenosis channel. The flow characteristics and transport of blood cells through the microstenosis were investigated with various flowrates. The mean velocity fields were nearly symmetric with respect to the channel centreline. In the contraction section, the oncoming blood flow was accelerated rapidly, and the maximum velocity at the throat was almost 4.99 times faster than that of the straight microchannel without stenosis. In the diffusion section, the blood cells show rolling, deformation, twisting, and tumbling motion due to the flow-choking characteristics at the stenotic region. The results from this study will provide useful basic data for comparison with those obtained by clinical researchers.
- Keywords
- haemodiluted blood flow; microstenosis; micro-particle image velocimetry; microcirculation; haematocrit; tumbling motion; rolling motion; STENOTIC VESSELS; MICROCIRCULATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/26568
- DOI
- 10.1243/09544119JEIM644
- ISSN
- 0954-4119
- Article Type
- Article
- Citation
- PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, vol. 224, no. H1, page. 17 - 25, 2010-01
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