DC Field | Value | Language |
---|---|---|
dc.contributor.author | Khan, AA | - |
dc.contributor.author | Lee, AJ | - |
dc.contributor.author | Roh, TY | - |
dc.date.accessioned | 2016-04-01T07:45:59Z | - |
dc.date.available | 2016-04-01T07:45:59Z | - |
dc.date.created | 2015-06-22 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 1750-1911 | - |
dc.identifier.other | 2015-OAK-0000033167 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/26848 | - |
dc.description.abstract | Polycomb group (PcG) proteins play an important role in the regulation of gene expression, especially genes encoding lineage-specific factors. Perturbations in PcG protein expression may trigger an unexpected developmental pathway, resulting in birth defects and developmental disabilities. Two Polycomb repressive complexes, PRC1 and PRC2, have been identified and are related with diverse cellular processes through histone modifications. Many developmental genes are trimethylated at histone H3 lysine 27 (H3K27me3) mediated by PRC2, which provides a binding site for PRC1. These processes contribute to chromatin compaction and transcriptional repression. In this review, we discuss about the complex formation of PcG proteins, the mechanism through which they are recruited to target sites and their functional roles in cell differentiation. | - |
dc.description.statementofresponsibility | archiving status unknown | - |
dc.language | English | - |
dc.publisher | FUTURE MEDICINE LTD | - |
dc.relation.isPartOf | EPIGENOMICS | - |
dc.title | Polycomb group protein-mediated histone modifications during cell differentiation | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.2217/EPI.14.61 | - |
dc.author.google | Khan, AA | - |
dc.author.google | Lee, AJ | - |
dc.author.google | Roh, TY | - |
dc.relation.volume | 7 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 75 | - |
dc.relation.lastpage | 84 | - |
dc.contributor.id | 10138348 | - |
dc.relation.journal | EPIGENOMICS | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EPIGENOMICS, v.7, no.1, pp.75 - 84 | - |
dc.identifier.wosid | 000349832500009 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 84 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 75 | - |
dc.citation.title | EPIGENOMICS | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Roh, TY | - |
dc.identifier.scopusid | 2-s2.0-84923262122 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 13 | - |
dc.description.scptc | 10 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Review | - |
dc.subject.keywordPlus | HOX GENE-EXPRESSION | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | H2A UBIQUITYLATION | - |
dc.subject.keywordPlus | TARGET GENES | - |
dc.subject.keywordPlus | NUCLEAR REORGANIZATION | - |
dc.subject.keywordPlus | EPIGENETIC REGULATION | - |
dc.subject.keywordPlus | COMPLEX PRC2 | - |
dc.subject.keywordPlus | EZH2 | - |
dc.subject.keywordPlus | CHROMATIN | - |
dc.subject.keywordAuthor | cell differentiation | - |
dc.subject.keywordAuthor | development | - |
dc.subject.keywordAuthor | homeobox genes | - |
dc.subject.keywordAuthor | PcG recruitment | - |
dc.subject.keywordAuthor | Polycomb group proteins | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
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