DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung-Eun Kim | - |
dc.contributor.author | Chang Suk Chae | - |
dc.contributor.author | Gi-Cheon Kim | - |
dc.contributor.author | Won Hwang | - |
dc.contributor.author | Ji-Sun Hwang | - |
dc.contributor.author | Sung-Min Hwang | - |
dc.contributor.author | Young Kim | - |
dc.contributor.author | Young-Tae Ahn | - |
dc.contributor.author | Sung-Gyoo Park | - |
dc.contributor.author | Chang-Duk Jun | - |
dc.contributor.author | Dipayan Rudra | - |
dc.contributor.author | Im, SH | - |
dc.date.accessioned | 2016-04-01T08:05:33Z | - |
dc.date.available | 2016-04-01T08:05:33Z | - |
dc.date.created | 2015-02-23 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.other | 2015-OAK-0000032041 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27208 | - |
dc.description.abstract | Although probiotics could confer health benefits to host physiology, their efficacy is strain specific. To identify anti-inflammatory probiotics, an ex vim screening system was developed, and validated effector functions of selected candidates using experimental rheumatoid arthritis as an in vivo model. Lactobacillus helveticus HY7801 was selected as the best candidate. Oral administration of L. helveticus HY7801 prevented the development of collagen-induced experimental arthritis, and diminished disease progression and severity by reducing antigen specific IgG levels and inflammatory immune response. Administration of L. helveticus HY7801 may induce regulatory CD11c+ dendritic cells, which in turn induce a phenotypic alteration of immune cells by reducing pro-inflammatory cytokines (TNF-alpha, IFN-gamma, and IL-17A) while enhancing anti-inflammatory cytoldne (IL-10) by CD4+T cells. This study suggests that screening of probiotic strains based on the IL-10(high)IL-12(low) selection criterion may be applicable to identify anti-inflammatory probiotics as an efficacious food for treating inflammatory immune responses including rheumatoid arthritis. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | JOURNAL OF FUNCTIONAL FOODS | - |
dc.title | Lactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1016/J.JFF.2015.01.002 | - |
dc.author.google | Kim J.-E. | - |
dc.author.google | Chae C.S. | - |
dc.author.google | Kim G.-C. | - |
dc.author.google | Hwang W. | - |
dc.author.google | Hwang J.-S. | - |
dc.author.google | Hwang S.-M. | - |
dc.author.google | Kim Y. | - |
dc.author.google | Ahn Y.-T. | - |
dc.author.google | Park S.-G. | - |
dc.author.google | Jun C.-D. | - |
dc.author.google | Rudra D. | - |
dc.author.google | Im S.-H. | - |
dc.relation.volume | 13 | - |
dc.relation.startpage | 350 | - |
dc.relation.lastpage | 362 | - |
dc.contributor.id | 10086785 | - |
dc.relation.journal | JOURNAL OF FUNCTIONAL FOODS | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNCTIONAL FOODS, v.13, pp.350 - 362 | - |
dc.identifier.wosid | 000350612800035 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 362 | - |
dc.citation.startPage | 350 | - |
dc.citation.title | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | Im, SH | - |
dc.identifier.scopusid | 2-s2.0-84922562059 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 9 | - |
dc.description.scptc | 7 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject.keywordPlus | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | - |
dc.subject.keywordPlus | GUT MICROBIOTA | - |
dc.subject.keywordPlus | METABOLIC INTERACTIONS | - |
dc.subject.keywordPlus | INTESTINAL MICROBIOTA | - |
dc.subject.keywordPlus | PROBIOTIC MIXTURE | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordAuthor | Cytokine | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Immune modulation | - |
dc.subject.keywordAuthor | Probiotics | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
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