DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yeom, J | - |
dc.contributor.author | Kim, SJ | - |
dc.contributor.author | Jung, H | - |
dc.contributor.author | Namkoong, H | - |
dc.contributor.author | Yang, J | - |
dc.contributor.author | Hwang, BW | - |
dc.contributor.author | Oh, K | - |
dc.contributor.author | KIM, KIMOON | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Hahn, SK | - |
dc.date.accessioned | 2016-04-01T08:06:29Z | - |
dc.date.available | 2016-04-01T08:06:29Z | - |
dc.date.created | 2015-02-04 | - |
dc.date.issued | 2015-01-28 | - |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.other | 2015-OAK-0000030986 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27235 | - |
dc.description.abstract | Synthetic hydrogels have been extensively investigated as artificial extracellular matrices (ECMs) for tissue engineering in vitro and in vivo. Crucial challenges for such hydrogels are sustaining long-term cytocompatible encapsulation and providing appropriate cues at the right place and time for spatio-temporal control of the cells. Here, in situ supramolecularly assembled and modularly modified hydrogels for long-term engineered mesenchymal stem cell (eMSC) therapy are reported using cucurbit[6]uril-conjugated hyaluronic acid (CB[6]-HA), diaminohexane conjugated HA (DAH-HA), and drug-conjugated CB[6] (drug-CB[6]). The eMSCs producing enhanced green fluorescence protein (EGFP) remain alive and emit the fluorescence within CB[6]/DAH-HA hydrogels in mice for more than 60 d. Furthermore, the long-term expression of mutant interleukin-12 (IL-12M) by eMSCs within the supramolecular hydrogels results in effective inhibition of tumor growth with a significantly enhanced survival rate. Taken together, these findings confirm the feasibility of supramolecular HA hydrogels as 3D artificial ECMs for cell therapies and tissue engineering applications. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | ADVANCED HEALTHCARE MATERIALS | - |
dc.title | Supramolecular Hydrogels for Long-Term Bioengineered Stem Cell Therapy | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1002/ADHM.201400304 | - |
dc.author.google | Yeom J. | - |
dc.author.google | Kim S.J. | - |
dc.author.google | Jung H. | - |
dc.author.google | Namkoong H. | - |
dc.author.google | Yang J. | - |
dc.author.google | Hwang B.W. | - |
dc.author.google | Oh K. | - |
dc.author.google | Kim K. | - |
dc.author.google | Sung Y.C. | - |
dc.author.google | Hahn S.K. | - |
dc.relation.volume | 4 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 237 | - |
dc.relation.lastpage | 244 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | ADVANCED HEALTHCARE MATERIALS | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ADVANCED HEALTHCARE MATERIALS, v.4, no.2, pp.237 - 244 | - |
dc.identifier.wosid | 000349051200008 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 244 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 237 | - |
dc.citation.title | ADVANCED HEALTHCARE MATERIALS | - |
dc.citation.volume | 4 | - |
dc.contributor.affiliatedAuthor | KIM, KIMOON | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.contributor.affiliatedAuthor | Hahn, SK | - |
dc.identifier.scopusid | 2-s2.0-84921875470 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 21 | - |
dc.description.scptc | 18 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | FATE | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
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