DC Field | Value | Language |
---|---|---|
dc.contributor.author | Goeun Lee | - |
dc.contributor.author | Na, YJ | - |
dc.contributor.author | Yang, BG | - |
dc.contributor.author | Choi, JP | - |
dc.contributor.author | Seo, YB | - |
dc.contributor.author | Hong, CP | - |
dc.contributor.author | Yun, CH | - |
dc.contributor.author | Kim, DH | - |
dc.contributor.author | Sohn, EJ | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Kim, YK | - |
dc.contributor.author | Jang, MH | - |
dc.contributor.author | Hwang, I | - |
dc.date.accessioned | 2016-04-01T08:06:30Z | - |
dc.date.available | 2016-04-01T08:06:30Z | - |
dc.date.created | 2015-02-04 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 1467-7644 | - |
dc.identifier.other | 2015-OAK-0000030977 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27236 | - |
dc.description.abstract | Pandemics in poultry caused by the highly pathogenic avian influenza (HPAI) A virus occur too frequently globally, and there is growing concern about the HPAI A virus due to the possibility of a pandemic among humans. Thus, it is important to develop a vaccine against HPAI suitable for both humans and animals. Various approaches are underway to develop such vaccines. In particular, an edible vaccine would be a convenient way to vaccinate poultry because of the behaviour of the animals. However, an edible vaccine is still not available. In this study, we developed a strategy of effective vaccination of mice by the oral administration of transgenic Arabidopsis plants (HA-TG) expressing haemagglutinin (HA) in the endoplasmic reticulum (ER). Expression of HA in the ER resulted in its high-level accumulation, N-glycosylation, protection from proteolytic degradation and long-term stability. Oral administration of HA-TG with saponin elicited high levels of HA-specific systemic IgG and mucosal IgA responses in mice, which resulted in protection against a lethal influenza virus infection with attenuated inflammatory symptoms. Based on these results, we propose that oral administration of freeze-dried leaf powders from transgenic plants expressing HA in the ER together with saponin is an attractive strategy for vaccination against influenza A virus. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.relation.isPartOf | Plant Biotechnology Journal | - |
dc.title | Oral immunization of haemaggulutinin H5 expressed in plant endoplasmic reticulum with adjuvant saponin protects mice against highly pathogenic avian influenza A virus infection | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1111/PBI.12235 | - |
dc.author.google | Lee G | - |
dc.author.google | Na YJ | - |
dc.author.google | Yang BG | - |
dc.author.google | Choi JP | - |
dc.author.google | Seo YB | - |
dc.author.google | Hong CP | - |
dc.author.google | Yun CH | - |
dc.author.google | Kim DH | - |
dc.author.google | Sohn EJ | - |
dc.author.google | Kim JH | - |
dc.author.google | Sung YC | - |
dc.author.google | Kim YK | - |
dc.author.google | Jang MH | - |
dc.author.google | Hwang I. | - |
dc.relation.volume | 13 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 62 | - |
dc.relation.lastpage | 72 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | PLANT BIOTECHNOLOGY JOURNAL | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Plant Biotechnology Journal, v.13, no.1, pp.62 - 72 | - |
dc.identifier.wosid | 000346915000007 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 72 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 62 | - |
dc.citation.title | Plant Biotechnology Journal | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.contributor.affiliatedAuthor | Hwang, I | - |
dc.identifier.scopusid | 2-s2.0-84919876807 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 14 | - |
dc.description.scptc | 11 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TRANS-GOLGI NETWORK | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | VACCINATION STRATEGIES | - |
dc.subject.keywordPlus | RESPIRATORY-TRACT | - |
dc.subject.keywordPlus | MUCOSAL IMMUNITY | - |
dc.subject.keywordPlus | CENTRAL VACUOLE | - |
dc.subject.keywordPlus | RECENT PROGRESS | - |
dc.subject.keywordPlus | CHOLERA-TOXIN | - |
dc.subject.keywordPlus | HEMAGGLUTININ | - |
dc.subject.keywordPlus | TRAFFICKING | - |
dc.subject.keywordAuthor | highly pathogenic avian influenza virus | - |
dc.subject.keywordAuthor | plant edible vaccine | - |
dc.subject.keywordAuthor | ER-targeted haemagglutinin | - |
dc.subject.keywordAuthor | adjuvant Saponin | - |
dc.subject.keywordAuthor | mucosal immunity | - |
dc.subject.keywordAuthor | influenza infection | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Plant Sciences | - |
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