DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, MY | - |
dc.contributor.author | Hong, CP | - |
dc.contributor.author | Park, SJ | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Yang, BG | - |
dc.contributor.author | Park, Y | - |
dc.contributor.author | Kim, SW | - |
dc.contributor.author | Kim, KS | - |
dc.contributor.author | Lee, JY | - |
dc.contributor.author | Lee, SW | - |
dc.contributor.author | Jang, MH | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2016-04-01T08:07:40Z | - |
dc.date.available | 2016-04-01T08:07:40Z | - |
dc.date.created | 2014-09-02 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 0017-5749 | - |
dc.identifier.other | 2015-OAK-0000030229 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27282 | - |
dc.description.abstract | Objective Programmed death-ligand 1 (PD-L1) has been shown to negatively regulate immune responses via its interaction with PD-1 receptor. In this study, we investigated the effects of PD-L1-Fc treatment on intestinal inflammation using two murine models of inflammatory colitis induced by dextran sulfate sodium (DSS) and T-cell transfer. Design The anti-colitis effect of adenovirus expressing Fc-conjugated PD-L1 (Ad/PD-L1-Fc) and recombinant PD-L1-Fc protein was evaluated in DSS-treated wild-type and Rag-1 knockout (KO) mice. We examined differentiation of T-helper cells, frequency of innate immune cells, and cytokine production by dendritic cells (DCs) in the colon from DSS-treated mice after PD-L1-Fc administration. In Rag-1 KO mice reconstituted with CD4 CD45RB(high) T cells, we assessed the treatment effect of PD-L1-Fc protein on the development of colitis. Results Administration of Ad/PD-L1-Fc significantly ameliorated DSS-induced colitis, which was accompanied by diminished frequency of interleukin (IL)-17A-producing CD4 T cells and increased interferon-gamma-producing CD4 T cells in the colon of DSS-fed mice. The anti-colitic effect of PD-L1-Fc treatment was also observed in DSS-treated Rag-1 KO mice, indicating lymphoid cell independency. PD-L1-Fc modulated cytokine production by colonic DCs and the effect was dependent on PD-1 expression. Furthermore, PD-L1-Fc protein could significantly reduce the severity of colitis in CD4 CD45RB(high) T-cell-transferred Rag-1 KO mice. Conclusions Based on the protective effect of PD-L1-Fc against DSS-induced and T-cell-induced colitis, our results suggest that PD-1-mediated inhibitory signals have a crucial role in limiting the development of colonic inflammation. This implicates that PD-L1-Fc may provide a novel therapeutic approach to treat inflammatory bowel disease. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | BMJ | - |
dc.relation.isPartOf | GUT | - |
dc.title | Protective effects of Fc-fused PD-L1 on two different animal models of colitis | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1136/GUTJNL-2014-307311 | - |
dc.author.google | Song M-Y. | - |
dc.author.google | Hong C.P. | - |
dc.author.google | Park S.J. | - |
dc.author.google | Kim J.H. | - |
dc.author.google | Yang B.-G. | - |
dc.author.google | Park Y. | - |
dc.author.google | Kim S.W. | - |
dc.author.google | Kim K.S. | - |
dc.author.google | Lee J.Y. | - |
dc.author.google | Lee S.-W. | - |
dc.author.google | Jang M.H. | - |
dc.author.google | Sung Y.-C. | - |
dc.relation.volume | 64 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 260 | - |
dc.relation.lastpage | 271 | - |
dc.contributor.id | 10113012 | - |
dc.relation.journal | GUT | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | GUT, v.64, no.2, pp.260 - 271 | - |
dc.identifier.wosid | 000348449800013 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 271 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 260 | - |
dc.citation.title | GUT | - |
dc.citation.volume | 64 | - |
dc.contributor.affiliatedAuthor | Lee, SW | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-84920873268 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 17 | - |
dc.description.scptc | 10 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INTESTINAL LAMINA PROPRIA | - |
dc.subject.keywordPlus | DSS-INDUCED COLITIS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
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