DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, G | - |
dc.contributor.author | Su Woong Yoo | - |
dc.contributor.author | Yebin Jung | - |
dc.contributor.author | Yeon-Mi Ryu | - |
dc.contributor.author | Youngrong Park | - |
dc.contributor.author | Kim, SY | - |
dc.contributor.author | Ki Hean Kim | - |
dc.contributor.author | Kim, S | - |
dc.contributor.author | Seung-Jae Myung | - |
dc.contributor.author | Euiheon Chung | - |
dc.date.accessioned | 2016-04-01T08:08:22Z | - |
dc.date.available | 2016-04-01T08:08:22Z | - |
dc.date.created | 2014-06-09 | - |
dc.date.issued | 2014-05-01 | - |
dc.identifier.issn | 2156-7085 | - |
dc.identifier.other | 2014-OAK-0000029965 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27309 | - |
dc.description.abstract | Intravital imaging has provided molecular, cellular and anatomical insight into the study of tumor. Early detection and treatment of gastrointestinal (GI) diseases can be enhanced with specific molecular markers and endoscopic imaging modalities. We present a wide-field multi-channel fluorescence endoscope to screen GI tract for colon cancer using multiple molecular probes targeting matrix metalloproteinases (MMP) conjugated with quantum dots (QD) in AOM/DSS mouse model. MMP9 and MMP14 antibody (Ab)-QD conjugates demonstrate specific binding to colonic adenoma. The average target-to-background (T/B) ratios are 2.10 +/- 0.28 and 1.78 +/- 0.18 for MMP14 Ab-QD and MMP9 Ab-QD, respectively. The overlap between the two molecular probes is 67.7 +/- 8.4%. The presence of false negative indicates that even more number of targeting could increase the sensitivity of overall detection given heterogeneous molecular expression in tumors. Our approach indicates potential for the screening of small or flat lesions that are precancerous. (C) 2014 Optical Society of America | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Optical Society of America | - |
dc.relation.isPartOf | BIOMEDICAL OPTICS EXPRESS | - |
dc.subject | TUMOR HETEROGENEITY | - |
dc.subject | TANDEM COLONOSCOPY | - |
dc.subject | QUANTUM DOTS | - |
dc.subject | LIVING MICE | - |
dc.subject | CANCER | - |
dc.subject | ENDOMICROSCOPY | - |
dc.subject | FEASIBILITY | - |
dc.subject | INHIBITION | - |
dc.subject | EXPRESSION | - |
dc.subject | COLITIS | - |
dc.title | Intravital imaging of mouse colonic adenoma using MMP-based molecular probes with multi-channel fluorescence endoscopy | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1364/BOE.5.001677 | - |
dc.author.google | Oh, G | - |
dc.author.google | Yoo, SW | - |
dc.author.google | Jung, Y | - |
dc.author.google | Ryu, YM | - |
dc.author.google | Park, Y | - |
dc.author.google | Kim, SY | - |
dc.author.google | Kim, KH | - |
dc.author.google | Kim, S | - |
dc.author.google | Myung, SJ | - |
dc.author.google | Chung, E | - |
dc.relation.volume | 5 | - |
dc.relation.issue | 5 | - |
dc.relation.startpage | 1677 | - |
dc.relation.lastpage | 1689 | - |
dc.contributor.id | 10183385 | - |
dc.relation.journal | BIOMEDICAL OPTICS EXPRESS | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOMEDICAL OPTICS EXPRESS, v.5, no.5, pp.1677 - 1689 | - |
dc.identifier.wosid | 000335494600029 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1689 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1677 | - |
dc.citation.title | BIOMEDICAL OPTICS EXPRESS | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | Yebin Jung | - |
dc.contributor.affiliatedAuthor | Ki Hean Kim | - |
dc.contributor.affiliatedAuthor | Kim, S | - |
dc.identifier.scopusid | 2-s2.0-84899745847 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 13 | - |
dc.description.scptc | 15 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TUMOR HETEROGENEITY | - |
dc.subject.keywordPlus | TANDEM COLONOSCOPY | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | LIVING MICE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ENDOMICROSCOPY | - |
dc.subject.keywordPlus | FEASIBILITY | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | COLITIS | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Optics | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Optics | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.