DC Field | Value | Language |
---|---|---|
dc.contributor.author | Martin, CE | - |
dc.contributor.author | van Leeuwen, EMM | - |
dc.contributor.author | Im, SJ | - |
dc.contributor.author | Roopenian, DC | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Surh, CD | - |
dc.date.accessioned | 2016-04-01T08:11:14Z | - |
dc.date.available | 2016-04-01T08:11:14Z | - |
dc.date.created | 2013-07-04 | - |
dc.date.issued | 2013-05-30 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.other | 2013-OAK-0000027752 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27419 | - |
dc.description.abstract | Interleukin-7 (IL-7) is essential to T-cell survival as well as homeostatic proliferation, and clinical trials that exploit the mitogenic effects of IL-7 have achieved success in treating human diseases. In mice, the in vivo potency of IL-7 improves dramatically when it is administered as a complex with the anti-IL-7 neutralizing monoclonal antibody clone M25. However, the mechanism whereby M25 augments IL-7 potency is unknown. We have analyzed the discrete contributions of the antibody constant (Fc) and IL-7-binding (Fab) domains to the mechanism. By engaging the neonatal Fc receptor the Fc domain extends the in vivo lifespan of IL-7/M25 complexes and accounts for the majority of their activity. Unexpectedly, the IL-7-neutralizing Fab domain provides an additional, albeit smaller, contribution, possibly by serving as a cytokine depot. This study is the first to demonstrate that the neutralizing aspect of the monoclonal antibody is directly involved in enhancing the potency of a cytokine with a single form of receptor. Lessons from the mechanism of IL-7/M25 complexes inform the design of next-generation cytokine therapeutics. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER SOC HEMATOLOGY | - |
dc.relation.isPartOf | BLOOD | - |
dc.subject | T-CELL HOMEOSTASIS | - |
dc.subject | IN-VIVO | - |
dc.subject | RECOMBINANT INTERLEUKIN-2 | - |
dc.subject | SELECTIVE STIMULATION | - |
dc.subject | MONOCLONAL-ANTIBODY | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | LYMPHOID ORGANS | - |
dc.subject | DEFICIENT MICE | - |
dc.subject | RECEPTOR | - |
dc.subject | ENHANCEMENT | - |
dc.title | IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1182/BLOOD-2012-08-449215 | - |
dc.author.google | Martin C.E., van Leeuwen E.M., Im S.J., Roopenian D.C., Sung Y.C., Surh C.D. | - |
dc.relation.volume | 121 | - |
dc.relation.issue | 22 | - |
dc.relation.startpage | 4484 | - |
dc.relation.lastpage | 4492 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | BLOOD | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BLOOD, v.121, no.22, pp.4484 - 4492 | - |
dc.identifier.wosid | 000321894100010 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 4492 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 4484 | - |
dc.citation.title | BLOOD | - |
dc.citation.volume | 121 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.contributor.affiliatedAuthor | Surh, CD | - |
dc.identifier.scopusid | 2-s2.0-84880848605 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 11 | - |
dc.description.scptc | 10 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | T-CELL HOMEOSTASIS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | RECOMBINANT INTERLEUKIN-2 | - |
dc.subject.keywordPlus | SELECTIVE STIMULATION | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | LYMPHOID ORGANS | - |
dc.subject.keywordPlus | DEFICIENT MICE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
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