DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, JS | - |
dc.contributor.author | Jung, YO | - |
dc.contributor.author | Oh, HJ | - |
dc.contributor.author | Park, SJ | - |
dc.contributor.author | Heo, YJ | - |
dc.contributor.author | Kang, CM | - |
dc.contributor.author | Kwok, SK | - |
dc.contributor.author | Ju, JH | - |
dc.contributor.author | Park, KS | - |
dc.contributor.author | Cho, ML | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Park, SH | - |
dc.contributor.author | Kim, HY | - |
dc.date.accessioned | 2016-04-01T08:12:27Z | - |
dc.date.available | 2016-04-01T08:12:27Z | - |
dc.date.created | 2013-02-27 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 0019-2805 | - |
dc.identifier.other | 2012-OAK-0000026599 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27467 | - |
dc.description.abstract | Interleukin (IL)-27 is a heterodimeric cytokine that is known to have both stimulatory and inhibitory functions during immune responses. We investigated the effects of IL-27 on arthritis and bone erosion in the murine collagen-induced arthritis (CIA) model. We demonstrate that the inhibitory effect of IL-27 on osteoclastogenesis is associated with interferon-? (IFN-?) production by using an IFN-? knockout mouse model. The IL-27-Fc was injected into both CIA and IFN-?-deficient mice. The effects of IL-27-Fc on osteoclast differentiation were evaluated both in vitro and in vivo. The IL-27-Fc-injected mice showed significantly lower arthritis indices and fewer tartrate-resistant acid-phosphatase-positive osteoclasts in their joint tissues than untreated mice. Interleukin-27 inhibited osteoclastogenesis from bone marrow-derived mononuclear cells in vitro, which was counteracted by the addition of anti-IFN-? antibody. The IL-27-Fc did not affect arthritis in IFN-? knockout mice. Interleukin-27 also suppressed osteoclast differentiation in human and intriguingly, it could promote the expression of IFN-? on priming osteoclasts. These results imply that IL-27 suppressed the generation of CIA and osteoclastogenesis, which were mediated by the induction of IFN-?. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | IMMUNOLOGY | - |
dc.title | Interleukin-27 suppresses osteoclastogenesis via induction of interferon-γ | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1111/J.1365-2567.2012.03622.X | - |
dc.author.google | Park J.-S., Jung Y.O., Oh H.-J., Park S.J., Heo Y.-J., Kang C.-M., Kwok S.-K., Ju J.H., Park K.S., Cho M.-L., Sung Y.-C., Park S.-H., Kim H.-Y. | - |
dc.relation.volume | 137 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 326 | - |
dc.relation.lastpage | 335 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | IMMUNOLOGY | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | IMMUNOLOGY, v.137, no.4, pp.326 - 335 | - |
dc.identifier.wosid | 000311389900006 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 335 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 326 | - |
dc.citation.title | IMMUNOLOGY | - |
dc.citation.volume | 137 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-84869838745 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 12 | - |
dc.description.scptc | 12 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | AUTOIMMUNE ENCEPHALOMYELITIS | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | P-28 SUBUNIT | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | IL-27 | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | collagen-induced arthritis | - |
dc.subject.keywordAuthor | interferon-gamma | - |
dc.subject.keywordAuthor | interleukin-27 | - |
dc.subject.keywordAuthor | interleukin-27-Fc | - |
dc.subject.keywordAuthor | osteoclastogenesis | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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