DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, MY | - |
dc.contributor.author | Yang, JA | - |
dc.contributor.author | Jung, HS | - |
dc.contributor.author | Beack, S | - |
dc.contributor.author | Choi, JE | - |
dc.contributor.author | Hur, W | - |
dc.contributor.author | Koo, H | - |
dc.contributor.author | Kim, K | - |
dc.contributor.author | Yoon, SK | - |
dc.contributor.author | Hahn, SK | - |
dc.date.accessioned | 2016-04-01T08:12:33Z | - |
dc.date.available | 2016-04-01T08:12:33Z | - |
dc.date.created | 2013-02-18 | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.other | 2012-OAK-0000026434 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27471 | - |
dc.description.abstract | Gold nanoparticles (AuNPs) have been extensively investigated as an emerging delivery-carrier of various biopharmaceuticals. Instead of nonspecific polyethylene glycol (PEG) conjugated interferon alpha (IFN alpha) for the clinical treatment of hepatitis C virus (HCV) Infection, in this work, a target-specific long-acting delivery system of IFN alpha was successfully developed using the hybrid materials of AuNP and hyaluronic add (HA). The HA-AuNP/IFN alpha complex was prepared by chemical binding of thiolated HA and physical binding of IFN alpha to AuNP. According to antiproliferation tests in Daudi cells, the HA-AuNP/IFN alpha complex showed a comparable biological activity to PEG-Intron with a highly enhanced stability in human serum. Even 7 days postinjection, HA-AuNP/IFN alpha complex was target-specifically delivered and remained in the murine liver tissue, whereas IFN alpha and PEG-Intron were not detected in the liver. Accordingly, HA-AuNP/IFN alpha complex significantly enhanced the expression of 2',5'-oligoadenylate synthetase 1 (OAS1) for innate immune responses to viral infection In the liver tissue, which was much higher than those by IFN alpha, PEG-Intron, and AuNP/IFN alpha complex. Taken together, the target specific HA-AuNP/IFN alpha complex was thought to be successfully applied to the systemic treatment of HCV infection. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACS NANO | - |
dc.relation.isPartOf | ACS NANO | - |
dc.title | Hyaluronic Acid-Gold Nanoparticle/Interferon alpha Complex for Targeted Treatment of Hepatitis C Virus Infection | - |
dc.type | Article | - |
dc.contributor.college | 신소재공학과 | - |
dc.identifier.doi | 10.1021/NN302538Y | - |
dc.author.google | Lee M.-Y., Yang J.-A., Jung H.S., Beack S., Choi J.E., Hur W., Ko | - |
dc.relation.volume | 6 | - |
dc.relation.issue | 11 | - |
dc.relation.startpage | 9522 | - |
dc.relation.lastpage | 9531 | - |
dc.contributor.id | 10149037 | - |
dc.relation.journal | ACS NANO | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ACS NANO, v.6, no.11, pp.9522 - 9531 | - |
dc.identifier.wosid | 000311521700020 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 9531 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 9522 | - |
dc.citation.title | ACS NANO | - |
dc.citation.volume | 6 | - |
dc.contributor.affiliatedAuthor | Hahn, SK | - |
dc.identifier.scopusid | 2-s2.0-84870425936 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 47 | - |
dc.description.scptc | 46 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | gold nanoparticle | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | interferon alpha | - |
dc.subject.keywordAuthor | targeted delivery | - |
dc.subject.keywordAuthor | hepatitis C virus | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
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