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Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway SCIE SCOPUS

Title
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
Authors
Han, JMJeong, SJPark, MCKim, GKwon, NHKim, HKHa, SHRyu, SHKim, S
Date Issued
2012-04-13
Publisher
cell
Abstract
Amino acids are required for activation of the mammalian target of rapamycin (mTOR) kinase, which regulates protein translation, cell size, and autophagy. However, the amino acid sensor that directly couples intracellular amino acid-mediated signaling to mTORC1 is unknown. Here we show that leucyl-tRNA synthetase (LRS) plays a critical role in amino acid-induced mTORC1 activation by sensing intracellular leucine concentration and initiating molecular events leading to mTORC1 activation. Mutation of LRS amino acid residues important for leucine binding renders the mTORC1 pathway insensitive to intracellular levels of amino acids. We show that LRS directly binds to Rag GTPase, the mediator of amino acid signaling to mTORC1, in an amino acid-dependent manner and functions as a GTPase-activating protein (GAP) for Rag GTPase to activate mTORC1. This work demonstrates that LRS is a key mediator for amino acid signaling to mTORC1.
URI
https://oasis.postech.ac.kr/handle/2014.oak/27478
DOI
10.1016/J.CELL.2012.02.044
ISSN
0092-8674
Article Type
Article
Citation
CELL, vol. 149, no. 2, page. 410 - 424, 2012-04-13
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류성호RYU, SUNG HO
Dept of Life Sciences
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