DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, S | - |
dc.contributor.author | Lee, KM | - |
dc.contributor.author | Ju, JH | - |
dc.contributor.author | Kim, J | - |
dc.contributor.author | Noh, DY | - |
dc.contributor.author | Lee, T | - |
dc.contributor.author | Shin, I | - |
dc.contributor.author | null | - |
dc.date.accessioned | 2016-04-01T08:14:00Z | - |
dc.date.available | 2016-04-01T08:14:00Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | IUBMB LIFE | - |
dc.identifier.citation | v.62 | - |
dc.identifier.citation | no.1 | - |
dc.identifier.citation | pp.41-50 | - |
dc.identifier.issn | 1521-6543 | - |
dc.identifier.other | 2010-OAK-0000020037 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27516 | - |
dc.description.abstract | MMTV-neu transgenic mice overexpressing NEU in their mammary glands develop tumor after 6 months of age. To find a novel protein biomarker using this mouse model, we identified and characterized the proteins that were differently expressed between primary mammary epithelial cells from 2 months old MMTV-neu heterozygote mice and wild type (WT) littermates using two-dimensional digest (ChemDigest (TM)/Trypsin)-LC-MS/MS. The differentially expressed proteins were selected and analyzed using DAVID Bioinformatics resource. The proteins involved in anti-apoptosis, purine metabolism, ribosome and proteasome functions were upregulated, whereas cell adhesion-related proteins were downregulated in PMECs from MMTV-neu mice when compared with WT PMECs. The results indicate that several functional units are coregulated by HER2/NEU. We hypothesize that these changes in the cellular proteome may be responsible for early onset of HER2/NEU-driven tumorigenesis. (C) 2009 IUBMB IUBMB Life, 62(1): 41-50, 2010 | - |
dc.description.statementofresponsibility | X | - |
dc.publisher | JOHN WILEY & SONS INC | - |
dc.subject | proteonomics | - |
dc.subject | signal transduction | - |
dc.subject | HER2/NEU | - |
dc.subject | HUMAN-BREAST-CANCER | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | RNA-POLYMERASE-II | - |
dc.subject | TRANSGENIC MICE | - |
dc.subject | ONCOGENE | - |
dc.subject | OVEREXPRESSION | - |
dc.subject | GROWTH | - |
dc.subject | GENE | - |
dc.subject | MECHANISM | - |
dc.subject | APOPTOSIS | - |
dc.title | Protein Expression Profiling of Primary Mammary Epithelial Cells Derived from MMTV-neu Mice Revealed that HER2/NEU-Driven Changes in Protein Expression Are Functionally Clustered | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/IUB.276 | - |
dc.author.google | Park, S | - |
dc.author.google | Lee, KM | - |
dc.author.google | Ju, JH | - |
dc.author.google | Kim, J | - |
dc.author.google | Noh, DY | - |
dc.author.google | Lee, T | - |
dc.author.google | Shin, I | - |
dc.relation.volume | 62 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 41 | - |
dc.relation.lastpage | 50 | - |
dc.publisher.location | US | - |
dc.relation.journal | IUBMB LIFE | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.docType | Article | - |
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