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Pineal function: Impact of microarray analysis
- Title
- Pineal function: Impact of microarray analysis
- Authors
- Klein, DC; Bailey, MJ; Carter, DA; Kim, JS; Shi, Q; Ho, AK; Chik, CL; Gaildrat, P; Morin, F; Ganguly, S; Rath, MF; Moller, M; Sugden, D; Rangel, ZG; Munson, PJ; Weller, JL; Coon, SL; null
- Date Issued
- 2010-01
- Publisher
- ELSEVIER IRELAND LTD
- Abstract
- Microarray analysis has provided a new understanding of pineal function by identifying genes that are highly expressed in this tissue relative to other tissues and also by identifying over 600 genes that are expressed on a 24-h schedule. This effort has highlighted surprising similarity to the retina and has provided reason to explore new avenues of study including intracellular signaling, signal transduction, transcriptional cascades, thyroid/retinoic acid hormone signaling, metal biology, RNA splicing, and the role the pineal gland plays in the immune/inflammation response. The new foundation that microarray analysis has provided will broadly support future research on pineal function. Published by Elsevier Ireland Ltd.
- Keywords
- Pineal; Microarray; Melatonin; Circadian rhythms; Cyclic AMP signaling; Immune response; Inflammation; MAP kinase; RNA splicing; ARYLALKYLAMINE N-ACETYLTRANSFERASE; ACTIVATED PROTEIN-KINASE; BETA-ADRENERGIC STIMULATION; THYROXINE 5'-DEIODINASE ACTIVITY; INTESTINAL-PEPTIDE STIMULATION; PRIMATE CEREBROSPINAL-FLUID; PHOSPHOLIPASE-C ACTIVITY; OTX2 HOMEOBOX GENE; RAT PINEAL; MELATONIN RHYTHM
- ISSN
- 0303-7207
- Article Type
- Conference
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