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Cited 139 time in webofscience Cited 154 time in scopus
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dc.contributor.authorPark, JW-
dc.contributor.authorKim, YJ-
dc.contributor.authorPark, CH-
dc.contributor.authorLee, DH-
dc.contributor.authorKo, YG-
dc.contributor.authorJang, JH-
dc.contributor.authorLee, CS-
dc.date.accessioned2016-04-01T08:16:04Z-
dc.date.available2016-04-01T08:16:04Z-
dc.date.created2010-02-01-
dc.date.issued2009-10-
dc.identifier.issn1742-7061-
dc.identifier.other2009-OAK-0000019865-
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/27592-
dc.description.abstractThis study investigated the surface characteristics and in vitro biocompatibility of ultrafine-grain pure titanium substrates produced by equal channel angular pressing (ECAP) using MC3T3-E1 pre-osteoblast cells, compared with those of conventional coarse-grain pure titanium (CP) and Ti-6Al-4V (Ti64) substrates. All Ti surfaces were grit-blasted with hydroxyapatite particles to produce microrough surfaces. The surface characteristics were evaluated by electron back-scattered diffractometry, scanning electron microscopy, contact angle and surface energy measurements, and optical profilometry. The morphology of spread cells, cell attachment, viability, alkaline phosphatase (ALP) activity, quantitative analysis of osteoblastic gene expression and mineralization nodule formation on different surfaces were evaluated. ECAP-processed substrates showed a significantly lower water contact angle and higher surface energy compared with coarse-grain CP and Ti64 substrates (p < 0.05). They also showed enhanced cell spreading, attachment, viability and ALP activity compared with the CP and Ti64 surfaces (p < 0.05). Real-time polymerase chain reaction analysis showed notably higher ALP, osteopontin and osteocalcin mRNA levels in cells grown on the ECAP surfaces than on the CP and Ti64 surfaces, and the ECAP surfaces showed significantly greater mineralization nodule formation compared with the CP and Ti64 substrates (p < 0.05). These results demonstrate the superior osteoblast cell compatibility of microroughened Ti surface made of ECAP-processed ultrafine-grain pure Ti substrates over coarse-grain pure Ti and Ti64 substrates. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.-
dc.description.statementofresponsibilityX-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.relation.isPartOfACTA BIOMATERIALIA-
dc.subjectUltrafine-grain titanium-
dc.subjectEqual channel angular pressing-
dc.subjectOsteoblast differentiation-
dc.subjectSurface wettability-
dc.subjectTitanium implant-
dc.subjectMETAL-IONS-
dc.subjectIN-VITRO-
dc.subjectNANOPHASE CERAMICS-
dc.subjectIMPLANT SURFACES-
dc.subjectCELLS-
dc.subjectBONE-
dc.subjectDIFFERENTIATION-
dc.subjectADHESION-
dc.subjectADSORPTION-
dc.subjectEXPRESSION-
dc.titleEnhanced osteoblast response to an equal channel angular pressing-processed pure titanium substrate with microrough surface topography-
dc.typeArticle-
dc.contributor.college신소재공학과-
dc.identifier.doi10.1016/J.ACTBIO.2009.04.038-
dc.author.googlePark, JW-
dc.author.googleKim, YJ-
dc.author.googlePark, CH-
dc.author.googleLee, DH-
dc.author.googleKo, YG-
dc.author.googleJang, JH-
dc.author.googleLee, CS-
dc.relation.volume5-
dc.relation.issue8-
dc.relation.startpage3272-
dc.relation.lastpage3280-
dc.contributor.id10071833-
dc.relation.journalACTA BIOMATERIALIA-
dc.relation.indexSCI급, SCOPUS 등재논문-
dc.relation.sciSCIE-
dc.collections.nameJournal Papers-
dc.type.rimsART-
dc.identifier.bibliographicCitationACTA BIOMATERIALIA, v.5, no.8, pp.3272 - 3280-
dc.identifier.wosid000271389700046-
dc.date.tcdate2019-02-01-
dc.citation.endPage3280-
dc.citation.number8-
dc.citation.startPage3272-
dc.citation.titleACTA BIOMATERIALIA-
dc.citation.volume5-
dc.contributor.affiliatedAuthorLee, CS-
dc.identifier.scopusid2-s2.0-70349152991-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.wostc97-
dc.description.scptc98*
dc.date.scptcdate2018-05-121*
dc.type.docTypeArticle-
dc.subject.keywordPlusMETAL-IONS-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusADHESION-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusADSORPTION-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusOSTEOPONTIN-
dc.subject.keywordPlusMETABOLISM-
dc.subject.keywordPlusROUGHNESS-
dc.subject.keywordAuthorUltrafine-grain titanium-
dc.subject.keywordAuthorEqual channel angular pressing-
dc.subject.keywordAuthorOsteoblast differentiation-
dc.subject.keywordAuthorSurface wettability-
dc.subject.keywordAuthorTitanium implant-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaMaterials Science-

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이종수LEE, CHONG SOO
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