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Synthesis of novel cholesterol-based cationic lipids for gene delivery
- Title
- Synthesis of novel cholesterol-based cationic lipids for gene delivery
- Date Issued
- 2009-01
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- The new cholesterol-based cationic lipids B, C, and D with an ether linked spacer were synthesized by using aminopropyl chain extension with acrylonitrile. The cholesterol-based cationic lipid A with carbamoyl linkage were also synthesized in order to compare the difference in transfection efficiency of the two linkage types. To this end, GFP expression of these cationic lipids was confirmed respectively. (C) 2009 Elsevier Ltd. All rights reserved.
- Keywords
- Cationic lipids; Gene delivery; Cholesterol derivatives; Cyanoethylation; TRANSFECTION; DERIVATIVES; LIPOPLEXES; POLYMERS; VECTORS; THERAPY; DESIGN; SERIES; SIRNA; SERUM
- ISSN
- 0960-894X
- Article Type
- Article
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