Angiogenic activity of human soluble intercellular adhesion molecule-1.
SCIE
SCOPUS
- Title
- Angiogenic activity of human soluble intercellular adhesion molecule-1.
- Authors
- Gho, YS; Hynda K Kleinman; Gabriel Sosne
- Date Issued
- 1999-10-15
- Publisher
- AMER ASSOC CANCER RESEARCH
- Abstract
- Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) are elevated in a number of pathological conditions associated with angiogenesis, including tumor growth. Because the increased levels of sICAM-1 suggested that it may be angiogenic, we tested the ability of sICAM-1 to promote angiogenesis, Human recombinant sICAM-1 stimulates chemokinetic endothelial cell migration, endothelial cell tube formation on Matrigel,and sprouting of aortic rings, sICAM-1 also mediates angiogenesis in the chick chorioallantoic membrane assay. Additionally, we found a M-r 49,000 molecule that binds to sICAM-1 that may be the surface Ligand on endothelial cells, The evidence that sICAM-1 has angiogenic activity suggests a possible role linking inflammation and neovascularization, Furthermore, sICAM-1 may enhance tumor growth by promoting angiogenesis and escape from immunosurveillance.
- Keywords
- MELANOMA CELL-LINES; ENDOTHELIAL-CELLS; ICAM-1; GROWTH; EXPRESSION; MATRIGEL; RELEASE; FORMS; MICE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/28388
- ISSN
- 0008-5472
- Article Type
- Article
- Citation
- CANCER RESEARCH, vol. 59, no. 20, page. 5128 - 5132, 1999-10-15
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- There are no files associated with this item.
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