DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Lee, HM | - |
dc.contributor.author | Jie, ST | - |
dc.contributor.author | Lee, SR | - |
dc.contributor.author | Mar, W | - |
dc.contributor.author | Gho, YS | - |
dc.date.accessioned | 2016-04-01T08:37:19Z | - |
dc.date.available | 2016-04-01T08:37:19Z | - |
dc.date.created | 2013-11-04 | - |
dc.date.issued | 2004-05-10 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.other | 2004-OAK-0000018241 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/28389 | - |
dc.description.abstract | Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is the most important angiogenic molecule associated with tumor-induced neovascularization. VEGF exerts its activity through binding to its receptor tyrosine kinase, KDR/Flk-1, expressed on the surface of endothelial cells. From the screening of medicinal plants, we have identified 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) from the roots of Paeonia lactiflora that inhibited the binding of VEGF to KDR/Flk-1. PGG efficiently blocked VEGF-induced human umbilical vein endothelial cell proliferation and the growth of immortalized human microvascular endothelial cells, but did not affect the growth of HT1080 human fibrosarcoma and DU-145 human prostate carcinoma cells. PGG also blocked VEGF-induced capillary-like tube formation of endothelial cell on Matrigel. Our results suggest that PGG could be a candidate for developing anti-angiogenic agent. (C) 2003 Elsevier Ireland Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI IRELAND LTD | - |
dc.relation.isPartOf | CANCER LETTERS | - |
dc.subject | 1,2,3,4.6-penta-O-galloyl-beta-D-glucose | - |
dc.subject | vascular endothelial growth factor | - |
dc.subject | KDR/Flk-1 | - |
dc.subject | angiogenesis | - |
dc.subject | cancer | - |
dc.subject | TUMOR-GROWTH | - |
dc.subject | CANCER-THERAPY | - |
dc.subject | IN-VITRO | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | METASTASIS | - |
dc.subject | VASCULOGENESIS | - |
dc.subject | EXPRESSION | - |
dc.subject | LETHALITY | - |
dc.subject | MITOGEN | - |
dc.subject | FLK-1 | - |
dc.title | 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor. | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.CANLET.200 | - |
dc.author.google | Lee, SJ | - |
dc.author.google | Lee, HM | - |
dc.author.google | Jie, ST | - |
dc.author.google | Lee, SR | - |
dc.author.google | Mar, W | - |
dc.author.google | Gho, YS | - |
dc.relation.volume | 208 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 89 | - |
dc.relation.lastpage | 94 | - |
dc.contributor.id | 10138843 | - |
dc.relation.journal | CANCER LETTERS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, v.208, no.1, pp.89 - 94 | - |
dc.identifier.wosid | 000221369000009 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 94 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 89 | - |
dc.citation.title | CANCER LETTERS | - |
dc.citation.volume | 208 | - |
dc.contributor.affiliatedAuthor | Gho, YS | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 32 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | VASCULOGENESIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | LETHALITY | - |
dc.subject.keywordPlus | MITOGEN | - |
dc.subject.keywordPlus | FLK-1 | - |
dc.subject.keywordAuthor | 1,2,3,4.6-penta-O-galloyl-beta-D-glucose | - |
dc.subject.keywordAuthor | vascular endothelial growth factor | - |
dc.subject.keywordAuthor | KDR/Flk-1 | - |
dc.subject.keywordAuthor | angiogenesis | - |
dc.subject.keywordAuthor | cancer | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.