DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gho, YS | - |
dc.contributor.author | Phillia N. Kim | - |
dc.contributor.author | Hao-Chuan Li | - |
dc.contributor.author | Michael Elkin | - |
dc.contributor.author | Hynda K Kleinman | - |
dc.date.accessioned | 2016-04-01T08:37:26Z | - |
dc.date.available | 2016-04-01T08:37:26Z | - |
dc.date.created | 2013-11-04 | - |
dc.date.issued | 2001-05-15 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.other | 2001-OAK-0000018236 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/28394 | - |
dc.description.abstract | Because serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) are elevated in cancer and sICAM-1 is angiogenic, we tested the ability of sICAM-1 to promote tumor growth. Our preliminary experiments showed that exogenous sICAM-1 significantly stimulated the growth of human tumors in vivo. Human fibrosarcoma transfectants, which express ICAM-1, produce ICAM-1 on the cell surface and release sICAM-1 into the medium without any apparent effect on cell growth in vitro. We found that conditioned medium from sense ICAM-1 transfectants compared with mock or antisense ICAM-1 transfectants stimulates endothelial cell migration in vitro and neovascularization in the chick chorioallantoic membrane assay. Tumor cells transfected with sense constructs form faster growing tumors than mock- and antisense-transfected cells in both chick embryos and nude mice models. Serum levels of human sICAM-1 from nude mice bearing sense ICAM-1 transfectants correlate positively with tumor weight. Sense ICAM-1 transfectants are more proliferative and induce more blood vessel formation than mock and anti-sense transfectants in nude mice. Because expression of ICAM-1 does not affect tumor cell growth in vitro, the angiogenic activity of sICAM-1 produced by sense ICAM-1 transfectants may be involved in the stimulation of tumor growth. Therefore, sICAM-1 may perform dual functions that are essential for tumor growth: angiogenesis and escape from immune surveillance. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.relation.isPartOf | CANCER RESEARCH | - |
dc.title | Stimulation of tumor growth by human soluble intercellular adhesion molecule-1. | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Gho, YS | - |
dc.author.google | Kim, PN | - |
dc.author.google | Li, HC | - |
dc.author.google | Elkin, M | - |
dc.author.google | Kleinman, HK | - |
dc.relation.volume | 61 | - |
dc.relation.issue | 10 | - |
dc.relation.startpage | 4253 | - |
dc.relation.lastpage | 4257 | - |
dc.contributor.id | 10138843 | - |
dc.relation.journal | CANCER RESEARCH | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH, v.61, no.10, pp.4253 - 4257 | - |
dc.identifier.wosid | 000168929600059 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 4257 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 4253 | - |
dc.citation.title | CANCER RESEARCH | - |
dc.citation.volume | 61 | - |
dc.contributor.affiliatedAuthor | Gho, YS | - |
dc.identifier.scopusid | 2-s2.0-0035872451 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 69 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CELL-ADHESION | - |
dc.subject.keywordPlus | ICAM-1 | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | FORMS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | ALPHA | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
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