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PREPARATION OF A 3 '-AZIDO-3 '-DEOXYTHYMIDINE (AZT) DERIVATIVE, WHICH IS BLOOD-BRAIN BARRIER PERMEABLE SCIE SCOPUS
- Title
- PREPARATION OF A 3 '-AZIDO-3 '-DEOXYTHYMIDINE (AZT) DERIVATIVE, WHICH IS BLOOD-BRAIN BARRIER PERMEABLE
- Date Issued
- 2009-08
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- The anti-AIDS drug AZT was covalently attached to the recently reported sorbitol-G8 transporter, and the conjugate was found to target mitochondria in HeLa cells and readily cross the blood-brain barrier (BBB) to gain access into the mouse brain, suggesting the potential of these molecular transporters as practical central nervous system (CNS) delivery vectors.
- Keywords
- CONTAINING MOLECULAR TRANSPORTERS; INTERNALIZATION MECHANISMS; DESIGN; THYMIDINE; DELIVERY; SYSTEM; DRUG; HIV; 3-AZIDO-3-DEOXYTHYMIDINE; AZIDOTHYMIDINE
- ISSN
- 1359-7345
- Article Type
- Article
- Citation
- CHEMICAL COMMUNICATIONS, no. 31, page. 4669 - 4671, 2009-08
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Related Researcher
- 김경태KIM, KYONG TAI
- Dept of Life Sciences