DC Field | Value | Language |
---|---|---|
dc.contributor.author | Roh, TY | - |
dc.contributor.author | Ngau, WC | - |
dc.contributor.author | Cui, KR | - |
dc.contributor.author | L | - |
dc.contributor.author | sman, D | - |
dc.contributor.author | Zhao, KJ | - |
dc.date.accessioned | 2016-04-01T08:52:58Z | - |
dc.date.available | 2016-04-01T08:52:58Z | - |
dc.date.created | 2009-08-18 | - |
dc.date.issued | 2004-08 | - |
dc.identifier.issn | 1087-0156 | - |
dc.identifier.other | 2005-OAK-0000016569 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/28975 | - |
dc.description.abstract | The expression patterns of eukaryotic genomes are controlled by their chromatin structure, consisting of nucleosome subunits in which DNA of approximately 146 bp is wrapped around a core of 8 histone molecules(1). Post-translational histone modifications play an essential role in modifying chromatin structure(.)(2) Here we apply a combination of SAGE 3 and chromatin immunoprecipitation (ChIP) protocols to determine the distribution of hyperacetylated histones H3 and H4 in the Saccharomyces cerevisiae genome. We call this approach genome-wide mapping technique (GMAT). Using GMAT, we find that the highest acetylation levels are detected in the 5 end of a gene's coding region, but not in the promoter. Furthermore, we show that the histone acetyltransferase, GCN5p, regulates H3 acetylation in the promoter and 5 end of the coding regions. These findings indicate that GMAT should find valuable applications in mapping target sites of chromatin-modifying enzymes. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | NATURE BIOTECHNOLOGY | - |
dc.subject | YEAST HETEROCHROMATIN | - |
dc.subject | ACETYLATION | - |
dc.subject | H4 | - |
dc.subject | TRANSCRIPTOME | - |
dc.subject | DEACETYLATION | - |
dc.subject | NUCLEOSOME | - |
dc.subject | TELOMERES | - |
dc.subject | PROMOTER | - |
dc.subject | GCN5P | - |
dc.title | High-resolution genome-wide mapping of histone modifications | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1038/NBT990 | - |
dc.author.google | Roh, TY | - |
dc.author.google | Ngau, WC | - |
dc.author.google | Cui, KR | - |
dc.author.google | Landsman, D | - |
dc.author.google | Zhao, KJ | - |
dc.relation.volume | 22 | - |
dc.relation.issue | 8 | - |
dc.relation.startpage | 1013 | - |
dc.relation.lastpage | 1016 | - |
dc.contributor.id | 10138348 | - |
dc.relation.journal | NATURE BIOTECHNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE BIOTECHNOLOGY, v.22, no.8, pp.1013 - 1016 | - |
dc.identifier.wosid | 000223039500031 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1016 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1013 | - |
dc.citation.title | NATURE BIOTECHNOLOGY | - |
dc.citation.volume | 22 | - |
dc.contributor.affiliatedAuthor | Roh, TY | - |
dc.identifier.scopusid | 2-s2.0-3543008920 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 149 | - |
dc.description.scptc | 159 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | YEAST HETEROCHROMATIN | - |
dc.subject.keywordPlus | ACETYLATION | - |
dc.subject.keywordPlus | H4 | - |
dc.subject.keywordPlus | TRANSCRIPTOME | - |
dc.subject.keywordPlus | DEACETYLATION | - |
dc.subject.keywordPlus | NUCLEOSOME | - |
dc.subject.keywordPlus | TELOMERES | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | GCN5P | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
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