DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wei, G | - |
dc.contributor.author | Wei, L | - |
dc.contributor.author | Zhu, JF | - |
dc.contributor.author | Zang, CZ | - |
dc.contributor.author | Hu-Li, J | - |
dc.contributor.author | Yao, ZJ | - |
dc.contributor.author | Cui, KR | - |
dc.contributor.author | Kanno, Y | - |
dc.contributor.author | Roh, TY | - |
dc.contributor.author | Watford, WT | - |
dc.contributor.author | Schones, DE | - |
dc.contributor.author | Peng, WQ | - |
dc.contributor.author | Sun, HW | - |
dc.contributor.author | Paul, WE | - |
dc.contributor.author | O'Shea, JJ | - |
dc.contributor.author | Zhao, KJ | - |
dc.date.accessioned | 2016-04-01T08:53:18Z | - |
dc.date.available | 2016-04-01T08:53:18Z | - |
dc.date.created | 2009-08-18 | - |
dc.date.issued | 2009-01 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.other | 2009-OAK-0000016556 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/28987 | - |
dc.description.abstract | Multipotential naive CD4(+) T cells differentiate into distinct lineages including T helper 1 (Th1), Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4(+) T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications or plasticity in T cell responses. We generated genome-wide histone H3 lysine 4 (H3K4) and lysine 27 (H3K27) trimethylation maps in naive, Th1, Th2, Th17, iTreg, and natural Treg (nTreg) cells. We found that although modifications of signature-cytokine genes (Ifng, II4, and II17) partially conform to the expectation of lineage commitment, genes encoding transcription factors like Tbx21 exhibit a broad spectrum of epigenetic states, consistent with our demonstration of T-bet and interferon-gamma induction in nTreg cells. Our data suggest an epigenetic mechanism underlying the specificity and plasticity of effector and regulatory T cells and also provide a framework for understanding complexity of CD4(+) T helper cell differentiation. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | IMMUNITY | - |
dc.title | GLOBAL MAPPING OF H3K4ME3 AND H3K27ME3 REVEALS SPECIFICITY AND PLASTICITY IN LINEAGE FATE DETERMINATION OF DIFFERENTIATING CD4(+) T CELLS | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/j.immuni.2008.12.009 | - |
dc.author.google | Wei, G | - |
dc.author.google | Wei, L | - |
dc.author.google | Zhu, JF | - |
dc.author.google | Zang, CZ | - |
dc.author.google | Hu-Li, J | - |
dc.author.google | Yao, ZJ | - |
dc.author.google | Cui, KR | - |
dc.author.google | Kanno, Y | - |
dc.author.google | Roh, TY | - |
dc.author.google | Watford, WT | - |
dc.author.google | Schones, DE | - |
dc.author.google | Peng, WQ | - |
dc.author.google | Sun, HW | - |
dc.author.google | Paul, WE | - |
dc.author.google | O'Shea, JJ | - |
dc.author.google | Zhao, KJ | - |
dc.relation.volume | 30 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 155 | - |
dc.relation.lastpage | 167 | - |
dc.contributor.id | 10138348 | - |
dc.relation.journal | IMMUNITY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | IMMUNITY, v.30, no.1, pp.155 - 167 | - |
dc.identifier.wosid | 000262769900018 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 167 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 155 | - |
dc.citation.title | IMMUNITY | - |
dc.citation.volume | 30 | - |
dc.contributor.affiliatedAuthor | Roh, TY | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 693 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | EMBRYONIC STEM-CELLS | - |
dc.subject.keywordPlus | HUMAN GENOME | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | FOXP3 EXPRESSION | - |
dc.subject.keywordPlus | HELPER TYPE-1 | - |
dc.subject.keywordPlus | T(H)17 CELLS | - |
dc.subject.keywordPlus | TH17 CELLS | - |
dc.subject.keywordPlus | TH2 CELLS | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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