DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, HW | - |
dc.contributor.author | Shin, ES | - |
dc.contributor.author | Lee, JE | - |
dc.contributor.author | Kwon, HS | - |
dc.contributor.author | Chun, E | - |
dc.contributor.author | Kim, SS | - |
dc.contributor.author | Chang, YS | - |
dc.contributor.author | Kim, YK | - |
dc.contributor.author | Min, KU | - |
dc.contributor.author | Kim, YY | - |
dc.contributor.author | Cho, SH | - |
dc.date.accessioned | 2016-04-01T09:05:22Z | - |
dc.date.available | 2016-04-01T09:05:22Z | - |
dc.date.created | 2009-03-05 | - |
dc.date.issued | 2007-03 | - |
dc.identifier.issn | 0040-6376 | - |
dc.identifier.other | 2007-OAK-0000010883 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/29433 | - |
dc.description.abstract | Background: Atopy is considered to be a complex genetic trait and does not follow a simple mendelian pattern of inheritance. It is now well recognised that gene - gene interactions are important in complex genetic disease. Aim: To analyse the influence of gene - gene interactions in the development of atopy. Methods: A total of 2055 ethnically identical participants aged 10 - 18 years living in rural areas on Jeju Island, Korea, were randomly recruited. Atopy was defined as a positive skin prick test response to one or more common inhalant allergens. Gene - gene interactions among 12 polymorphic loci were analysed in the seven candidate genes of atopy using the multidimensionality-reduction method. Results: A significant interaction was found between V297I in the gene coding vascular endothelial growth factor receptor 2 (KDR) and - 308G -> A in the gene coding tumour necrosis factor (TNF)alpha on the risk of atopy, with a cross-validation consistency of 10 out of 10 and a prediction error of 35.9% (p = 0.001). Conventional logistic regression also revealed significant interactions between KDR and TNF for atopy. Individuals with the variant allele of - 308G -> A in TNF (GA or AA) and V2971 in KDR (VI or II) had a significantly higher risk of atopy (OR 2.23; 95% CI 1.48 to 3.57). Conclusion: KDR and TNF may synergistically influence the development of atopy through gene - gene interaction in Korean children and adolescents. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | B M J PUBLISHING GROUP | - |
dc.relation.isPartOf | THORAX | - |
dc.subject | GENE-GENE INTERACTIONS | - |
dc.subject | TNF-ALPHA | - |
dc.subject | INTERLEUKIN-4 RECEPTOR | - |
dc.subject | ASTHMA | - |
dc.subject | POLYMORPHISMS | - |
dc.subject | ASSOCIATION | - |
dc.subject | IGE | - |
dc.subject | POPULATION | - |
dc.subject | PROMOTER | - |
dc.subject | VARIANT | - |
dc.title | Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1136/THX.2006.065 | - |
dc.author.google | Park, HW | - |
dc.author.google | Shin, ES | - |
dc.author.google | Lee, JE | - |
dc.author.google | Kwon, HS | - |
dc.author.google | Chun, E | - |
dc.author.google | Kim, SS | - |
dc.author.google | Chang, YS | - |
dc.author.google | Kim, YK | - |
dc.author.google | Min, KU | - |
dc.author.google | Kim, YY | - |
dc.author.google | Cho, | - |
dc.relation.volume | 62 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 265 | - |
dc.relation.lastpage | 269 | - |
dc.contributor.id | 10103891 | - |
dc.relation.journal | THORAX | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | THORAX, v.62, no.3, pp.265 - 269 | - |
dc.identifier.wosid | 000244562000015 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 269 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 265 | - |
dc.citation.title | THORAX | - |
dc.citation.volume | 62 | - |
dc.contributor.affiliatedAuthor | Kim, YK | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 16 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GENE-GENE INTERACTIONS | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | RECEPTOR-ALPHA | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | VARIANT | - |
dc.subject.keywordPlus | SENSITIZATION | - |
dc.subject.keywordPlus | HAPLOTYPES | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
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