Effect of hyaluronic acid molecular weight on the morphology of quantum dot-hyaluronic acid conjugates
SCIE
SCOPUS
- Title
- Effect of hyaluronic acid molecular weight on the morphology of quantum dot-hyaluronic acid conjugates
- Authors
- Kim, J; Park, K; Hahn, SK
- Date Issued
- 2008-01-01
- Publisher
- ELSEVIER SCIENCE BV
- Abstract
- The morphological analysis of novel quantum dot-hyaluronic acid (QDot-HA) conjugates was carried outwith a transmission electron microscope (TEM). Adipic acid dihydrazide-modified HA (HA-ADH) was synthesized and conjugated to quantum dots (QDots) having carboxyl terminal ligands which were activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysulfosuccinimide (sulfo-NHS). HA molecules with a molecular weight (MW) of 20 K, 234 K and 3000 K were used to investigate the effect of MW on the morphology of QDot-HA conjugates. The TEM micrographs of QDot-HA conjugates showed branched and multi-layered chain type morphology formed by inter- and intra-molecular conjugation of QDots to HA molecules. The size of QDot-HA conjugate increased with the MW of HA. QDot-HA conjugate could be successfully used for real-time bio-imaging of HA derivatives in nude mice. The novel QDot-HA conjugate will be further used to investigate the biological roles of HA with a different MW in the body. (c) 2007 Published by Elsevier B.V.
- Keywords
- quantum dots; hyaluronic acid; conjugates; TEM images; bio-imaging; SUSTAINED-RELEASE FORMULATION; IN-VIVO; CELLS; OLIGOSACCHARIDES; NANOPARTICLES; ENCAPSULATION; HYDROGELS; DELIVERY
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/29502
- DOI
- 10.1016/j.ijbiomac.2007.09.002
- ISSN
- 0141-8130
- Article Type
- Article
- Citation
- INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 42, no. 1, page. 41 - 45, 2008-01-01
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