DC Field | Value | Language |
---|---|---|
dc.contributor.author | Motokawa, K | - |
dc.contributor.author | Hahn, SK | - |
dc.contributor.author | Nakamura, T | - |
dc.contributor.author | Miyamoto, H | - |
dc.contributor.author | Shimoboji, T | - |
dc.date.accessioned | 2016-04-01T09:09:52Z | - |
dc.date.available | 2016-04-01T09:09:52Z | - |
dc.date.created | 2009-08-24 | - |
dc.date.issued | 2006-09-01 | - |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.other | 2006-OAK-0000010707 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/29570 | - |
dc.description.abstract | A novel sustained release formulation of erythropoietin (EPO) was developed using hyaluronic acid (HA) hydrogels. For the preparation of HA hydrogels, adipic acid dihydrazide grafted HA (HA-ADH) was synthesized and analyzed with H-1 NMR. The degree of HA-ADH modification was about 69%. EPO was in situ encapsulated into HA-ADH hydrogels through a selective cross-linking reaction of bis(sulfosuccinimidyl) suberate (BS3) to hydrazide group (pK(a) = 3.0) of HA-ADH rather than to amine group (pK(a) > 9) of EPO. The denaturation of EPO during HA-ADH hydrogel synthesis was drastically reduced with decreasing pH from 7.4 to 4.8. The specific reactivity of BS3 to hydrazide at pH = 4.8 might be due to its low pKa compared with that of amine. In vitro release of EPO in phosphate buffered saline at 37 degrees C showed that EPO was released rapidly for 2 days and then slowly up to 4 days from HA-ADH hydrogels. When the hydrogels were dried at 37 degrees C for a day, however, longer release of EPO up to 3 weeks could be demonstrated. According to in vivo release test of EPO from HA-ADH hydrogels in SD rats, elevated EPO concentration higher than 0.1 ng/mL could be maintained from 7 days up to 18 days depending on the preparation methods of HAADH hydrogels. There was no adverse effect during and after HA-ADH hydrogel implantation. (c) 2006 Wiley Periodicals, Inc. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | WILEY-LISS | - |
dc.relation.isPartOf | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.subject | sustained release | - |
dc.subject | erythropoietin | - |
dc.subject | hyaluronic acid | - |
dc.subject | crosslinking | - |
dc.subject | hydrogel | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | FUNCTIONALIZED DERIVATIVES | - |
dc.subject | CHEMICAL-MODIFICATION | - |
dc.subject | SODIUM HYALURONATE | - |
dc.subject | BIOMATERIALS | - |
dc.subject | PROTEINS | - |
dc.title | Selectively crosslinked hyaluronic acid hydrogels for sustained release formulation of erythropoietin | - |
dc.type | Article | - |
dc.contributor.college | 신소재공학과 | - |
dc.identifier.doi | 10.1002/JBM.A.30757 | - |
dc.author.google | Motokawa, K | - |
dc.author.google | Hahn, SK | - |
dc.author.google | Nakamura, T | - |
dc.author.google | Miyamoto, H | - |
dc.author.google | Shimoboji, T | - |
dc.relation.volume | 78A | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 459 | - |
dc.relation.lastpage | 465 | - |
dc.contributor.id | 10149037 | - |
dc.relation.journal | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, v.78A, no.3, pp.459 - 465 | - |
dc.identifier.wosid | 000239613800004 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 465 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 459 | - |
dc.citation.title | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.citation.volume | 78A | - |
dc.contributor.affiliatedAuthor | Hahn, SK | - |
dc.identifier.scopusid | 2-s2.0-33748853349 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 30 | - |
dc.description.scptc | 3 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | FUNCTIONALIZED DERIVATIVES | - |
dc.subject.keywordPlus | CHEMICAL-MODIFICATION | - |
dc.subject.keywordPlus | SODIUM HYALURONATE | - |
dc.subject.keywordPlus | BIOMATERIALS | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordAuthor | sustained release | - |
dc.subject.keywordAuthor | erythropoietin | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | crosslinking | - |
dc.subject.keywordAuthor | hydrogel | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
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