DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gho, YS | - |
dc.contributor.author | Yoon, WH | - |
dc.contributor.author | Chae, CB | - |
dc.date.accessioned | 2016-04-01T09:17:12Z | - |
dc.date.available | 2016-04-01T09:17:12Z | - |
dc.date.created | 2013-11-04 | - |
dc.date.issued | 2002-03-22 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.other | 2002-OAK-0000010410 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/29799 | - |
dc.description.abstract | It has been suggested that angiogenin binds to an actin-like molecule present on the surface of endothelial cells. Actin inhibits plasmin activity, but the angiogenin-actin complex is not active. In this report, we found that plasmin inhibits the interaction between angiogenin and actin suggesting a possibility that both angiogenin and plasmin may bind to a similar site on actin. Here we report that chANG, an antiangiogenin peptide that binds to the actin-binding site of angiogenin, inhibits the proteolytic activity of plasmin without any apparent effect on the activities of plasminogen activators and matrix metalloproteases. Its antiplasmin activity is comparable with that of actin. chANG inhibits plasmin activity via its binding to plasmin kringle domains while scrambled chANG does not bind to plasmin. chANG also inhibits the invasion of angiogenin-secreting human fibrosarcoma and colorectal carcinoma cells without effecting migration. Furthermore, chANG blocks angiogenesis induced by fibrosarcoma cells and metastasis of colorectal carcinoma cells to the liver. Therefore, the 11-amino acid peptide chANG has both antiangiogenin and antiplasmin activity, and could be useful in the development of anticancer agents. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLO | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.subject | ARTERY ENDOTHELIAL-CELLS | - |
dc.subject | PLASMINOGEN-ACTIVATOR | - |
dc.subject | PHOSPHOLIPASE-C | - |
dc.subject | CARCINOMA-CELLS | - |
dc.subject | ACTIN | - |
dc.subject | RIBONUCLEASE | - |
dc.subject | PROTEIN | - |
dc.subject | ACID | - |
dc.subject | COMPLEMENTARY | - |
dc.subject | SEQUENCE | - |
dc.title | Antiplasmin activity of a peptide that binds to the receptor-binding site of angiogenin | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1074/jbc.M105526200 | - |
dc.author.google | Gho, YS | - |
dc.author.google | Yoon, WH | - |
dc.author.google | Chae, CB | - |
dc.relation.volume | 277 | - |
dc.relation.issue | 12 | - |
dc.relation.startpage | 9690 | - |
dc.relation.lastpage | 9694 | - |
dc.contributor.id | 10138843 | - |
dc.relation.journal | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.277, no.12, pp.9690 - 9694 | - |
dc.identifier.wosid | 000174549200013 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 9694 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 9690 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 277 | - |
dc.contributor.affiliatedAuthor | Gho, YS | - |
dc.identifier.scopusid | 2-s2.0-0037155852 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 14 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ARTERY ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | PLASMINOGEN-ACTIVATOR | - |
dc.subject.keywordPlus | PHOSPHOLIPASE-C | - |
dc.subject.keywordPlus | CARCINOMA-CELLS | - |
dc.subject.keywordPlus | ACTIN | - |
dc.subject.keywordPlus | RIBONUCLEASE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | COMPLEMENTARY | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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