DC Field | Value | Language |
---|---|---|
dc.contributor.author | Na, BR | - |
dc.contributor.author | Kim, HR | - |
dc.contributor.author | Piragyte, I | - |
dc.contributor.author | Oh, HM | - |
dc.contributor.author | Kwon, MS | - |
dc.contributor.author | Akber, U | - |
dc.contributor.author | Lee, HS | - |
dc.contributor.author | Park, DS | - |
dc.contributor.author | Song, WK | - |
dc.contributor.author | Park, ZY | - |
dc.contributor.author | Im, SH | - |
dc.contributor.author | Rho, MC | - |
dc.contributor.author | Hyun, YM | - |
dc.contributor.author | Kim, M | - |
dc.contributor.author | Jun, CD | - |
dc.date.accessioned | 2016-04-08T07:33:22Z | - |
dc.date.available | 2016-04-08T07:33:22Z | - |
dc.date.created | 2016-03-02 | - |
dc.date.issued | 2015-04-13 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.other | 2015-OAK-0000035490 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/29897 | - |
dc.description.abstract | The formation of an immunological synapse (IS) requires tight regulation of actin dynamics by many actin polymerizing/depolymerizing proteins. However, the significance of actin stabilization at the IS remains largely unknown. In this paper, we identify a novel function of TAGLN2-an actin-binding protein predominantly expressed in T cells-in stabilizing cortical F-actin, thereby maintaining F-actin contents at the IS and acquiring LFA-1 (leukocyte function-associated antigen-1) activation after T cell receptor stimulation. TAGLN2 blocks actin depolymerization and competes with cofilin both in vitro and in vivo. Knockout of TAGLN2 (TAGLN2(-/-)) reduced F-actin content and destabilized F-actin ring formation, resulting in decreased cell adhesion and spreading. TAGLN2(-/-) T cells displayed weakened cytokine production and cytotoxic effector function. These findings reveal a novel function of TAGLN2 in enhancing T cell responses by controlling actin stability at the IS. | - |
dc.description.statementofresponsibility | open | - |
dc.language | English | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.relation.isPartOf | JOURNAL OF CELL BIOLOGY | - |
dc.subject | ARP2/3 COMPLEX | - |
dc.subject | F-ACTIN | - |
dc.subject | RETROGRADE FLOW | - |
dc.subject | PHORBOL ESTER | - |
dc.subject | ALPHA-ACTININ | - |
dc.subject | IN-VIVO | - |
dc.subject | PROTEIN | - |
dc.subject | COFILIN | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | ASSOCIATION | - |
dc.title | TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1083/JCB.201407130 | - |
dc.author.google | Na, BR | - |
dc.author.google | Kim, HR | - |
dc.author.google | Piragyte, I | - |
dc.author.google | Oh, HM | - |
dc.author.google | Kwon, MS | - |
dc.author.google | Akber, U | - |
dc.author.google | Lee, HS | - |
dc.author.google | Park, DS | - |
dc.author.google | Song, WK | - |
dc.author.google | Park, ZY | - |
dc.author.google | Im, SH | - |
dc.author.google | Rho, MC | - |
dc.author.google | Hyun, YM | - |
dc.author.google | Kim, M | - |
dc.author.google | Jun, CD | - |
dc.relation.volume | 209 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 143 | - |
dc.relation.lastpage | 162 | - |
dc.contributor.id | 10086785 | - |
dc.relation.journal | JOURNAL OF CELL BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELL BIOLOGY, v.209, no.1, pp.143 - 162 | - |
dc.identifier.wosid | 000352960200015 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 162 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 143 | - |
dc.citation.title | JOURNAL OF CELL BIOLOGY | - |
dc.citation.volume | 209 | - |
dc.contributor.affiliatedAuthor | Im, SH | - |
dc.identifier.scopusid | 2-s2.0-84928248290 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 17 | - |
dc.description.scptc | 12 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ARP2/3 COMPLEX | - |
dc.subject.keywordPlus | F-ACTIN | - |
dc.subject.keywordPlus | RETROGRADE FLOW | - |
dc.subject.keywordPlus | PHORBOL ESTER | - |
dc.subject.keywordPlus | ALPHA-ACTININ | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | COFILIN | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
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