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Cited 95 time in webofscience Cited 109 time in scopus
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Computer-aided multiple-head 3D printing system for printing of heterogeneous organ/tissue constructs SCIE SCOPUS

Title
Computer-aided multiple-head 3D printing system for printing of heterogeneous organ/tissue constructs
Authors
Jung, JWLee, JSCho, DW
Date Issued
2016-02-22
Publisher
NATURE PUBLISHING GROUP
Abstract
Recently, much attention has focused on replacement or/and enhancement of biological tissues via the use of cell-laden hydrogel scaffolds with an architecture that mimics the tissue matrix, and with the desired three-dimensional (3D) external geometry. However, mimicking the heterogeneous tissues that most organs and tissues are formed of is challenging. Although multiple-head 3D printing systems have been proposed for fabricating heterogeneous cell-laden hydrogel scaffolds, to date only the simple exterior form has been realized. Here we describe a computer-aided design and manufacturing (CAD/CAM) system for this application. We aim to develop an algorithm to enable easy, intuitive design and fabrication of a heterogeneous cell-laden hydrogel scaffolds with a free-form 3D geometry. The printing paths of the scaffold are automatically generated from the 3D CAD model, and the scaffold is then printed by dispensing four materials; i.e., a frame, two kinds of cell-laden hydrogel and a support. We demonstrated printing of heterogeneous tissue models formed of hydrogel scaffolds using this approach, including the outer ear, kidney and tooth tissue. These results indicate that this approach is particularly promising for tissue engineering and 3D printing applications to regenerate heterogeneous organs and tissues with tailored geometries to treat specific defects or injuries.
Keywords
CELL-LADEN; TISSUE; SCAFFOLDS; BIOMATERIALS; ARCHITECTURE; HYDROGELS
URI
https://oasis.postech.ac.kr/handle/2014.oak/29990
DOI
10.1038/SREP21685
ISSN
2045-2322
Article Type
Article
Citation
SCIENTIFIC REPORTS, vol. 6, page. 21685, 2016-02-22
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조동우CHO, DONG WOO
Dept of Mechanical Enginrg
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