DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, JY | - |
dc.contributor.author | Kwon, SH | - |
dc.contributor.author | Park, JW | - |
dc.contributor.author | Park, SM | - |
dc.date.accessioned | 2017-07-18T17:04:11Z | - |
dc.date.available | 2017-07-18T17:04:11Z | - |
dc.date.created | 2009-03-16 | - |
dc.date.issued | 2008-06-30 | - |
dc.identifier.issn | 0003-2670 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/31136 | - |
dc.description.abstract | We report preparation of a novel platform for effective DNA hybridization and its application to the detection of single mismatched DNA. Cone-shaped dendrimer molecules have been immobilized on the gold surface at equidistance, 3.1 nm, from each other with a probe DNA molecule attached to the top of each dendrimer so that enough space would be secured for effective hybridization. This arrangement allows each probe DNA molecule to form a natural DNA double helix upon hybridization with a target DNA molecule. The single nucleotide polymorphism at either the central or end position of the 25-mer target DNA has been shown to be effectively discriminated against on this platform from each other as well as from a complementary DNA by electrochemical impedance measurements. We also report adverse effects exerted by probe ions, Fe(CN)(6)(3-/4-), on DNA hybridization reactions. The significance of the results for the use in DNA analysis is discussed. (C) 2008 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | ANALYTICA CHIMICA ACTA | - |
dc.subject | self-assembled monolayer of dendrimer molecules | - |
dc.subject | monodispersed self-assembled monolayer | - |
dc.subject | electrochemical impedance spectroscopy | - |
dc.subject | spacer | - |
dc.subject | dioxyribonucleic acid analysis | - |
dc.subject | FOURIER-TRANSFORM | - |
dc.subject | HYBRIDIZATION | - |
dc.subject | TEMPLATES | - |
dc.subject | POLYMERS | - |
dc.subject | MICROARRAYS | - |
dc.subject | ELECTRODES | - |
dc.subject | SENSORS | - |
dc.subject | SURFACE | - |
dc.subject | GROWTH | - |
dc.title | Label-free detection of DNA molecules on the dendron based self-assembled monolayer by electrochemical impedance spectroscopy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.aca.2008.02.055 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ANALYTICA CHIMICA ACTA, v.619, no.1, pp.37 - 42 | - |
dc.identifier.wosid | 000257269700008 | - |
dc.date.tcdate | 2019-03-01 | - |
dc.citation.endPage | 42 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 37 | - |
dc.citation.title | ANALYTICA CHIMICA ACTA | - |
dc.citation.volume | 619 | - |
dc.contributor.affiliatedAuthor | Park, JW | - |
dc.contributor.affiliatedAuthor | Park, SM | - |
dc.identifier.scopusid | 2-s2.0-44649139283 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 29 | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.subject.keywordPlus | FOURIER-TRANSFORM | - |
dc.subject.keywordPlus | HYBRIDIZATION | - |
dc.subject.keywordPlus | TEMPLATES | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | MICROARRAYS | - |
dc.subject.keywordPlus | ELECTRODES | - |
dc.subject.keywordPlus | SENSORS | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | self-assembled monolayer of dendrimer molecules | - |
dc.subject.keywordAuthor | monodispersed self-assembled monolayer | - |
dc.subject.keywordAuthor | electrochemical impedance spectroscopy | - |
dc.subject.keywordAuthor | spacer | - |
dc.subject.keywordAuthor | dioxyribonucleic acid analysis | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
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