Open Access System for Information Sharing

Login Library

 

Article
Cited 261 time in webofscience Cited 308 time in scopus
Metadata Downloads

Biomimetic 3D tissue printing for soft tissue regeneration SCIE SCOPUS

Title
Biomimetic 3D tissue printing for soft tissue regeneration
Authors
Pati, FHa, DHJang, JHan, HHRhie, JWCho, DW
Date Issued
2015-09
Publisher
ELSEVIER SCI LTD
Abstract
Engineered adipose tissue constructs that are capable of reconstructing soft tissue with adequate volume would be worthwhile in plastic and reconstructive surgery. Tissue printing offers the possibility of fabricating anatomically relevant tissue constructs by delivering suitable matrix materials and living cells. Here, we devise a biomimetic approach for printing adipose tissue constructs employing decellularized adipose tissue (DAT) matrix bioink encapsulating human adipose tissue-derived mesenchymal stem cells (hASCs). We designed and printed precisely-defined and flexible dome-shaped structures with engineered porosity using DAT bioink that facilitated high cell viability over 2 weeks and induced expression of standard adipogenic genes without any supplemented adipogenic factors. The printed DAT constructs expressed adipogenic genes more intensely than did non-printed DAT gel. To evaluate the efficacy of our printed tissue constructs for adipose tissue regeneration, we implanted them subcutaneously in mice. The constructs did not induce chronic inflammation or cytotoxicity postimplantation, but supported positive tissue infiltration, constructive tissue remodeling, and adipose tissue formation. This study demonstrates that direct printing of spatially on-demand customized tissue analogs is a promising approach to soft tissue regeneration. (c) 2015 Elsevier Ltd. All rights reserved.
URI
https://oasis.postech.ac.kr/handle/2014.oak/35362
DOI
10.1016/J.BIOMATERIALS.2015.05.043
ISSN
0142-9612
Article Type
Article
Citation
BIOMATERIALS, vol. 62, page. 164 - 175, 2015-09
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

조동우CHO, DONG WOO
Dept of Mechanical Enginrg
Read more

Views & Downloads

Browse