Tunicate-mimetic nanofibrous hydrogel adhesive with improved wet adhesion
SCIE
SCOPUS
- Title
- Tunicate-mimetic nanofibrous hydrogel adhesive with improved wet adhesion
- Authors
- Oh, DX; Kim, S; Lee, D; Hwang, DS
- Date Issued
- 2015-07-01
- Publisher
- Elsevier Ltd
- Abstract
- The main impediment to medical application of biomaterial-based adhesives is their poor wet adhesion strength due to hydration-induced softening and dissolution. To solve this problem, we mimicked the wound healing process found in tunicates, which use a nanofiber structure and pyrogallol group to heal any damage on its tunic under sea water. We fabricated a tunicate-mimetic hydrogel adhesive based on a chitin nanofiber/gallic acid (a pyrogallol acid) composite. The pyrogallol group-mediated cross-linking and the nanofibrous structures improved the dissolution resistance and cohesion strength of the hydrogel compared to the amorphous polymeric hydrogels in wet condition. The tunicate-mimetic adhesives showed higher adhesion strength between fully hydrated skin tissues than did fibrin glue and mussel-mimetic adhesives. The tunicate mimetic hydrogels were produced at low cost from recyclable and abundant raw materials. This tunicate-mimetic adhesive system is an example of how natural materials can be engineered for biomedical applications. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/35517
- DOI
- 10.1016/J.ACTBIO.2015.03.031
- ISSN
- 1742-7061
- Article Type
- Article
- Citation
- ACTA BIOMATERIALIA, vol. 20, page. 104 - 112, 2015-07-01
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