DC Field | Value | Language |
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dc.contributor.author | Shin, Y | - |
dc.contributor.author | Yoon, CH | - |
dc.contributor.author | Lim, H | - |
dc.contributor.author | Park, J | - |
dc.contributor.author | Roh, TY | - |
dc.contributor.author | Kang, C | - |
dc.contributor.author | Choi, BS | - |
dc.date.accessioned | 2017-07-19T12:17:52Z | - |
dc.date.available | 2017-07-19T12:17:52Z | - |
dc.date.created | 2016-01-22 | - |
dc.date.issued | 2015-08-07 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/35590 | - |
dc.description.abstract | Regarding the T cell function in HIV-1 infection, activation of T cells is enhanced in acutely HIV-1-infected T cells upon stimuli. However, T cell immune responses underlying the activation of T cell receptor (TCR) signaling molecules and interleukin (IL)-2 production in latently HIV-1-infected cells are poorly understood. The expression and activation of TCR components and its downstream molecules in acutely and latently HIV-1-infected T cells were compared using quantitative reverse transcription polymerase chain reaction (RT-PCR) for mRNA expression and enzyme-linked immunosorbent assay (ELISA) for levels of IL-2 in phytohemagglutinin M (PHA-M). The levels of T cell surface molecules and TCR signaling molecules in latently HIV-1-infected cells were greatly decreased without changes in their mRNA levels. In addition, downstream TCR-signaling molecules in latently HIV-1-infected cells were not activated even in the presence of PHA-M. The phosphorylation of mitogen-activated protein kinases (MAPKs) in the presence of PHA-M was weakly induced in latently HIV-1-infected cells but was greater in acutely HIVNL4-3-infected cells. Finally, the production of IL-2 was significantly decreased in latently HIV-1-infected cells compared with uninfected parent cells. Thus, IL-2-related immunological functions in latently HIV-1-infected T cells were markedly impaired even in the presence of stimuli. (C) 2015 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.title | Impaired IL-2 expression in latent HIV-1 infection | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/J.BBRC.2015.06.091 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.463, no.4, pp.1237 - 1242 | - |
dc.identifier.wosid | 000358455300121 | - |
dc.date.tcdate | 2019-03-01 | - |
dc.citation.endPage | 1242 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1237 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 463 | - |
dc.contributor.affiliatedAuthor | Roh, TY | - |
dc.identifier.scopusid | 2-s2.0-84940460188 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 1 | - |
dc.description.scptc | 1 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | T-CELL-ACTIVATION | - |
dc.subject.keywordPlus | IMMUNOLOGICAL SYNAPSE | - |
dc.subject.keywordPlus | NEF | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | NFAT | - |
dc.subject.keywordPlus | AP-1 | - |
dc.subject.keywordAuthor | Latent HIV-1 infection | - |
dc.subject.keywordAuthor | TCR-downstream signaling molecules | - |
dc.subject.keywordAuthor | MAPKs | - |
dc.subject.keywordAuthor | IL-2 | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
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