DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shim, JU | - |
dc.contributor.author | Lee, SE | - |
dc.contributor.author | Hwang, W | - |
dc.contributor.author | Lee, C | - |
dc.contributor.author | Park, JW | - |
dc.contributor.author | Sohn, JH | - |
dc.contributor.author | Nam, JH | - |
dc.contributor.author | Kim, Y | - |
dc.contributor.author | Rhee, JH | - |
dc.contributor.author | Im, SH | - |
dc.contributor.author | Koh, YI | - |
dc.date.accessioned | 2017-07-19T12:26:48Z | - |
dc.date.available | 2017-07-19T12:26:48Z | - |
dc.date.created | 2016-03-02 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/35831 | - |
dc.description.abstract | Background: Although the hygiene hypothesis suggests that microbial infections could subvert asthma and thus a microbial product might serve as a therapeutic adjuvant for asthma, the relationship between bacterial components and asthma is complex. Recently, low levels of flagellin, the Toll-like receptor (TLR) 5 ligand, have been reported to promote asthma. Objective: We show that a therapeutic dose of flagellin suppresses asthma and that the effect occurs through generating regulatory dendritic cells (rDCs) and regulatory T (Treg) cells. Methods: Ovalbumin (OVA)-induced wild-type and TLR5 knockout asthmatic mice were treated intranasally with a mixture of OVA and 10 mu g of a flagellin B (FlaB; of Vibrio vulnificus). OVA/FlaB-treated rDCs were adoptively transferred to mice with OVA-induced asthma. Anti-CD25 mAb was used to deplete Treg cells. A mixture of house dust mite (HDM) and FlaB was used to treat mice with HDM-induced asthma. Blood CD14(+) monocyte-derived dendritic cells from HDM-sensitive asthmatic patients were treated with FlaB and incubated with autologous CD14(+) T cells. Results: An OVA/FlaB mixture ameliorated OVA-induced asthma by inhibiting T(H)1/T(H)2/T(H)17 responses in a TLR5-dependent manner through generating rDCs and Treg cells. The adoptive transfer of OVA/FlaB-treated dendritic cells inhibited OVA-induced asthma, whereas the depletion of CD25(+) cells eliminated the inhibitory effect. A similar effect of FlaB was observed in mice with HDM-induced asthma. In patients with HDM-sensitive asthma, FlaB-treated rDCs inhibited HDM-stimulated T(H)1/T(H)2 responses while enhancing Treg cells in an IL-10-dependent manner. Conclusion: These findings collectively suggest that flagellin could be used as a tolerogenic adjuvant to treat allergic asthma. | - |
dc.language | English | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.relation.isPartOf | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.title | Flagellin suppresses experimental asthma by generating regulatory dendritic cells and T cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/J.JACI.2015.07.010 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, v.137, no.2, pp.426 - 435 | - |
dc.identifier.wosid | 000369235500011 | - |
dc.date.tcdate | 2019-03-01 | - |
dc.citation.endPage | 435 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 426 | - |
dc.citation.title | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.citation.volume | 137 | - |
dc.contributor.affiliatedAuthor | Im, SH | - |
dc.identifier.scopusid | 2-s2.0-84957936317 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 16 | - |
dc.description.scptc | 11 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ADJUVANT ACTIVITY | - |
dc.subject.keywordPlus | FUSION PROTEIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordPlus | FOXP3 | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | HYPERREACTIVITY | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordAuthor | Asthma | - |
dc.subject.keywordAuthor | Toll-like receptor 5 | - |
dc.subject.keywordAuthor | flagellin | - |
dc.subject.keywordAuthor | dendritic cells | - |
dc.subject.keywordAuthor | regulatory T cells | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
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