Open Access System for Information Sharing

Login Library

 

Article
Cited 32 time in webofscience Cited 38 time in scopus
Metadata Downloads

A New Method of Fabricating a Blend Scaffold using an Indirect Three-dimensional Printing Technique SCIE SCOPUS

Title
A New Method of Fabricating a Blend Scaffold using an Indirect Three-dimensional Printing Technique
Authors
Jung, JWLee, HHong, JMPark, JHShim, JHChoi, THCho, DW
Date Issued
2015-12
Publisher
IOP PUBLISHING LTD
Abstract
Due to its simplicity and effectiveness, the physical blending of polymers is considered to be a practical strategy for developing a versatile scaffold having desirable mechanical and biochemical properties. In the present work, an indirect three-dimensional (i3D) printing technique was proposed to fabricate a 3D free-form scaffold using a blend of immiscible materials, such as polycaprolactone (PCL) and gelatin. The i3D printing technique includes 3D printing of a mold and a sacrificial molding process. PCL/chloroform and gelatin/water were physically mixed to prepare the blend solution, which was subsequently injected into the cavity of a 3D printed mold. After solvent removal and gelatin cross-linking, the mold was dissolved to obtain a PCL-gelatin (PG) scaffold, with a specific 3Dstructure. Scanning electron microscopy and Fourier transform infrared spectroscopy analysis indicated that PCL masses and gelatin fibers in the PG scaffold homogenously coexisted without chemical bonding. Compression tests confirmed that gelatin incorporation into the PCL enhanced its mechanical flexibility and softness, to the point of being suitable for soft-tissue engineering, as opposed to pure PCL. Human adipose-derived stem cells, cultured on a PG scaffold, exhibited enhanced in vitro chondrogenic differentiation and tissue formation, compared with those on a PCL scaffold. The i3D printing technique can be used to blend a variety of materials, facilitating 3D scaffold fabrication for specific tissue regeneration. Furthermore, this convenient and versatile technique may lead to wider application of 3D printing in tissue engineering.
URI
https://oasis.postech.ac.kr/handle/2014.oak/35856
DOI
10.1088/1758-5090/7/4/045003
ISSN
1758-5082
Article Type
Article
Citation
BIOFABRICATION, vol. 7, no. 4, 2015-12
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

조동우CHO, DONG WOO
Dept of Mechanical Enginrg
Read more

Views & Downloads

Browse