Nanoscale graphene coating on commercially pure titanium for accelerated bone regeneration
SCIE
SCOPUS
- Title
- Nanoscale graphene coating on commercially pure titanium for accelerated bone regeneration
- Authors
- Jung, HS; Choi, YJ; Jeong, J; Lee, Y; Hwang, B; Jang, J; Shim, JH; Kim, YS; Choi, HS; Oh, SH; Lee, CS; Cho, DW; Hahn, SK
- Date Issued
- 2016-03
- Publisher
- Royal Society of Chemistry
- Abstract
- Titanium (Ti) is one of the representative biocompatible metallic materials which has been widely exploited for various implants and bone replacements. Here, commercially pure Ti (CP Ti) was surface-modified with reduced graphene oxide (RGO) for accelerated bone regeneration and osseointegration. Nanoscale RGO coating on CP Ti was clearly confirmed by SEM, AFM, EDS, XPS, HR-TEM and EELS. In addition, pre-osteoblast cells cultured on RGO-CP Ti showed higher cell viability and cell attachment than those on CP Ti. After confirmation of the drug loading capability of RGO-CP Ti, osteogenic dexamethasone loaded RGO-CP Ti (Dex/RGO-CP Ti) was implanted on calvarial bone defects in rats. Synchrotron X-ray imaging successfully visualized more effective bone regeneration on Dex/RGO-CP Ti than CP Ti and RGO-CP Ti after 8 weeks.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/36098
- DOI
- 10.1039/C6RA03905G
- ISSN
- 2046-2069
- Article Type
- Article
- Citation
- RSC Advances, vol. 6, no. 32, page. 26719 - 26724, 2016-03
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